Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 213-926-7 | CAS number: 1067-25-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1994-11-22 to 1994-11-25
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.3 (Algal Inhibition test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: Stock solution and all treatments at the start (0 h) and end (72 h) of the test.
- Sampling method: A separate sample was prepared in the same way the test medium was prepared, but without algae and NaHCO3-nutrient solution. - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: Test media were prepared by dilution of a 1000 mg/L stock solution in VE water. The stock solution was prepared by mixing for 18 h followed by filtration. The determined TOC concentration of the stock solution was 445 mg/L. - Test organisms (species):
- Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)
- Details on test organisms:
- TEST ORGANISM
- Common name: Aquatic algae
- Strain: 86.81.SAG
- Source: Institute for Water, Ground and Air Hygiene, Berlin (Germany) and subsequent in-house breeding
- Age of inoculum (at test initiation): 3 days
- Method of cultivation: In sterile, aerated Erlenmeyer flasks on light tables. A pre-culture is produced from an original culture by super-inoculation three days before the test begins. From this culture the test cultures are inoculated at a density of about 20000 cells/ml. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 72 h
- Hardness:
- no data
- Test temperature:
- 24 ± 2 ºC
- pH:
- Start of test: 8.3 - 8.7
End of test: 8.6 - 8.7 - Dissolved oxygen:
- no data
- Salinity:
- not applicable
- Nominal and measured concentrations:
- Nominal concentrations: 0 (control), 101, 172, 304, 507 and 913 mg/l
Measured concentration (0 h): 0, 99, 161, 311, 550, and 975 mg/L
Measured concentration (72 h): 0, 84, 148, 260, 475 and 1000 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: Erlenmeyer flasks
- Type: Open
- Material: glass
- Aeration: none
- Initial cell density: 20000 cells/ml
- Control end cell density: 560000 cells/ml
- No. of vessels per concentration (replicates): 5
- No. of vessels per control (replicates): 8
GROWTH MEDIUM
- Standard medium used: Yes
TEST MEDIUM / WATER PARAMETERS
- Culture medium different from test medium: No
- Intervals of water quality measurement: Start and end of test
OTHER TEST CONDITIONS
- Sterile test conditions: yes
- Adjustment of pH: No
- Photoperiod: continuous
- Light intensity and quality: 8000 Lux (white light)
EFFECT PARAMETERS MEASURED:
- Determination of cell concentrations: spectrophotometer (absorption at 685 nm) at 0 h, 24 h, 48 h and 72 h
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 1.7 - Reference substance (positive control):
- no
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 913 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- but exposure is to hydrolysis products
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 913 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- but exposure is to hydrolysis products
- Basis for effect:
- growth rate
- Details on results:
- - Exponential growth in the control: Yes
- Observation of abnormalities: None reported
- Any stimulation of growth found in any treatment: No - Reported statistics and error estimates:
- The were no toxic effects observed in the highest test concentrations and therefore statistical analysis of the results was not carried out.
- Validity criteria fulfilled:
- yes
- Conclusions:
- An EC50 (72 h) value of > 913 mg/L and a NOEC (72 h) of ≥ 913 mg/L were obtained for the effects of the test substance on the growth rate of Scenedesmus subspicatus based on nominal concentrations. However, it is likely that the test organisms were exposed to the hydrolysis products of the substance.
Reference
ANALYTICAL RESULTS
The deviation of the geometric mean measured concentrations from the nominal concentration was < 20%. Therefore, it was concluded that the test item (parent compound or its hydrolysis products) remained bioavailable and did not disappear by potential biodegradation, volatilization or adsorption to the vessel. Results were thus based on nominal concentrations.
EXPERIMENTAL RESULTS
Table 1. Test results
Nominal test substance concentration (mg/l) | Mean cell density at start of test (cells/ml) | Mean cell density after 24 hours (cells/ml) | Mean cell density after 48 hours (cells/ml) | Mean cell density after 72 hours (cells/ml) |
0 (Control) | 20000 | 20000 | 140000 | 560000 |
101 | 20000 | 20000 | 160000 | 710000 |
172 | 20000 | 30000 | 170000 | 710000 |
304 | 20000 | 30000 | 200000 | 760000 |
507 | 20000 | 30000 | 180000 | 730000 |
913 | 20000 | 50000 | 220000 | 800000 |
Description of key information
ErC50 (72 h) value of > 913 mg/L (nominal, EU method C3, S. subspicatus, RL1), equivalent to > 679 mg/L when expressed in terms of the silanol hydrolysis product
NOErC (72 h) of ≥ 913 mg/L (nominal, EU method C3, S. subspicatus, RL1), equivalent to ≥ 679 mg/L when expressed in terms of the silanol hydrolysis product
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 679 mg/L
- EC10 or NOEC for freshwater algae:
- 679 mg/L
Additional information
A 72 h EC50 of > 913 mg/l and a NOEC (72 h) of ≥ 913 mg/l were obtained for the effects of the substance on the growth rate of the algae Scenedesmus subspicatus (new name: Desmodesmus subspicatus) (EU Method C.3 (Algal Inhibition test) based on nominal concentrations.
Since the substance hydrolyses rapidly (half-life approximately 2.6 hours) to propylsilanetriol, under ecotoxicity testing conditions, the organisms were predominantly exposed to the hydrolysis product.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.