Registration Dossier
Registration Dossier
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EC number: 295-322-3 | CAS number: 91995-60-7
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Data are available for TAME. The lowest 48-h EC50 is 100 mg/l in Daphnia magna. For marine invertebrates the 96-h LC50 is 14 mg/l in Americamysis bahia.
The outcome of these studies is used to support the derivation of an effect concentration as a weighted average of the predicted values for the components of the substance.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Marine water invertebrates
Marine water invertebrates
- Effect concentration:
- 14 mg/L
Additional information
Based on the considerations described in the document “Read-across substantiation C5-6 branched alkylmethyl-ethers” (incl. the supporting references Tuppurainen et al., 2007 and Niska et al., 2008), it can be concluded that the available information can be usedto predict the short-term toxicity to aquatic intervertebrates of the substance ‘C5-6 branched alkylmethyl-ethers’ with sufficient certainty.
In order to take the indicated higher ecotoxicological potential of the other components of the C5-6 branched alkylmethyl-ethers (compared to the TAME) into account, a weighted average value was calculated:
Endpoint |
Weighted average (mg/l) |
Acute toxicity to daphnids |
88 |
The outcome of the following studies is used to support the derivation of an effect concentration as a weighted average of the predicted values for the components of the substance (see attachments for details):
There are several guideline studies on TAME available for freshwater invertebrates. The most critical study for is therefore chosen as the key study. For freshwater invertebrates the lowest observed effect concentration is a 48-h EC50 value of 100 mg/l inDaphnia magna(Springborn Laboratories, Inc., 1994b). For marine invertebrates only one study was available, the study was conducted according to accepted guidelines, the 96-h LC50 is 14 mg/l inAmericamysis bahia(Springborn Laboratories Inc,., 1994c).
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