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Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1986

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
yes
Remarks:
The stimulus index on the intact skin is determined in a modified form according to Gilman et al (5).
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2,4-triazole-3-thiol
EC Number:
221-656-6
EC Name:
1,2,4-triazole-3-thiol
Cas Number:
3179-31-5
Molecular formula:
C2H3N3S
IUPAC Name:
4H-1,2,4-triazole-3-thiol
Test material form:
solid: crystalline

Test animals

Species:
rabbit
Strain:
Himalayan

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
water
Controls:
yes, concurrent no treatment
Amount / concentration applied:
0.5 g test substance in 0.25 ml aqua dest.
The application site was covered with a roughly 6.25 large linen cloth that adheres to a synthetic adhesive film. An occlusion dressing applied in a circular manner around the trunk (Acrylastic, P. 2408, width 8 on) served to seal off the outside.
Duration of treatment / exposure:
4 hour (occlusive patch)
Observation period:
3 days p. appl.
Number of animals:
3 (two male, one female)

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritation parameter:
edema score
Basis:
animal #1
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritation parameter:
edema score
Basis:
animal #2
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritation parameter:
edema score
Basis:
animal #3
Time point:
24/48/72 h
Score:
0
Max. score:
4

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
A single application of 0.5 g 3-Mercapto-1,2,4,-triazol each on the intact skin of 3 rabbits caused no changes.
The irritation index is 0.0. 3-Mercapto-1,2,4,-triazol has no irritating properties on the skin of the rabbit.
Systemic-toxic effects did not occur after a single application of the test product. The general condition of the experimental animals was undisturbed.
Executive summary:

3-Mercapto-1,2,4,-triazol was tested for its primarily skin-irritating properties on rabbits. 0.5 g each was applied to the back skin of 3 test animals. The test product did not cause any skin reactions. The average stimulus index is: 0.0.