Registration Dossier
Registration Dossier
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EC number: 942-582-7 | CAS number: -
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Read-across
- Justification for type of information:
- See attached document below.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 720 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Conclusions:
- Based on a worse case approach taking into account the highest toxicity observed to Daphnia magna with the 3 source substances [Potassium sulfate (CAS 7778-80-5), Sodium sulfate (CAS 7757-82-6) and Calcium sulfate (CAS 7778-18-9)], the 48h-EC50 value of 720 mg/L was attributed to the target substance "Sulfates of potassium, sodium and calcium, by-product from fermentation”. According to CLP criteria, this substance is not classified for its toxicity to aquatic invertebrates.
- Executive summary:
The results on the acute toxicity to invertebrates are indicative of a similar very low toxicity of the 3 sulfates salts. The 48h-EC50 to Daphnia magna obtained for Potassium sulfate, Sodium sulfate and Calcium sulfate are 720 mg/L, 1766 mg/L and 1500 mg/L respectively. These extremely high values demonstrate the lack of adverse effects of the 3 source substances to Daphnia magna. No acute toxicity study to invertebrates is available for the registered substance “Sulfates of potassium, sodium and calcium, by-product from fermentation”. However taking into account the data available on the three sulfate salts, the registered substance is not considered to be hazardous for aquatic invertebrates. Based on a worse case approach, the lowest 48h-EC50 on Daphnia magna obtained with the 3 sulfate salts, namely 720 mg/L, is attributed to the target substance “Sulfates of potassium, sodium and calcium, by-product from fermentation” as representative of its acute toxicity to aquatic invertebrates.
According to CLP criteria, this substance is not classified for its toxicity to aquatic invertebrates.
Reference
Description of key information
Based on a worse case approach taking into account the highest toxicity observed to Daphnia magna with the 3 source substances [Potassium sulfate (CAS 7778-80-5), Sodium sulfate (CAS 7757-82-6) and Calcium sulfate (CAS 7778-18-9)], the 48h-EC50 value of 720 mg/L was attributed to the target substance "Sulfates of potassium, sodium and calcium, by-product from fermentation”. According to CLP criteria, this substance is not classified for its toxicity to aquatic invertebrates.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 720 mg/L
Additional information
The results on the acute toxicity to invertebrates are indicative of a similar very low toxicity of the 3 sulfates salts. The 48h-EC50 to Daphnia magna obtained for Potassium sulfate, Sodium sulfate and Calcium sulfate are 720 mg/L, 1766 mg/L and 1500 mg/L respectively. These extremely high values demonstrate the lack of adverse effects of the 3 source substances to Daphnia magna. No acute toxicity study to invertebrates is available for the registered substance “Sulfates of potassium, sodium and calcium, by-product from fermentation”. However taking into account the data available on the three sulfate salts, the registered substance is not considered to be hazardous for aquatic invertebrates. Based on a worse case approach, the lowest 48h-EC50 on Daphnia magna obtained with the 3 sulfate salts, namely 720 mg/L, is attributed to the target substance “Sulfates of potassium, sodium and calcium, by-product from fermentation” as representative of its acute toxicity to aquatic invertebrates.
According to CLP criteria, this substance is not classified for its toxicity to aquatic invertebrates.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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