Registration Dossier
Registration Dossier
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EC number: 224-167-6 | CAS number: 4221-98-1
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017-04-21 to 2017-04-26
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- yes
- Remarks:
- With respect to the test design, no phase separation via centrifugation is necessary.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- Council Regulation (EC) No. 260/2014, Method A.6 modified according to Letinski et al. (2002) and OECD 123 (2006)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 4.37 mg/L
- Conc. based on:
- test mat.
- Incubation duration:
- 72 h
- Temp.:
- 20 °C
- pH:
- 5.6
- Conclusions:
- The water solubility of the test item was determined to be 4.37 mg/L at 20°C pH 5.6.
- Executive summary:
The water solubility of the test item was determined according to GLP, OECD guideline 105 (1995) and Council Regulation (EC) No. 260/2014, Method A.6, modified according to Letinski et al. (2002) and OECD 123 (2006). The solubility of the test item in double distilled water was determined employing the flask method with slow stirring approach at 20 ± 0.5 °C with incubation at test temperature for 72 h before the first sampling.
The analytical method (GC-MS, external standard) for the determination of the test item was validated and tested with satisfactory results in regard to linearity, accuracy, precision and specificity.
The water solubility of the test item was determined to be 4.37 mg/L at 20°C pH 5.6.
Reference
Description of key information
The water solubility of the test item was determined to be 4.37 mg/L at 20°C pH 5.6.
Key value for chemical safety assessment
- Water solubility:
- 4.37 mg/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test item was determined according to GLP, OECD guideline 105 (1995) and Council Regulation (EC) No. 260/2014, Method A.6, modified according to Letinski et al. (2002) and OECD 123 (2006). The solubility of the test item in double distilled water was determined employing the flask method with slow stirring approach at 20 ± 0.5 °C with incubation at test temperature for 72 h before the first sampling.
The analytical method (GC-MS, external standard) for the determination of the test item was validated and tested with satisfactory results in regard to linearity, accuracy, precision and specificity.
The water solubility of the test item was determined to be 4.37 mg/L at 20°C pH 5.6.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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