Isooctadecanoic acid, reaction products with tetraethylenepentamine

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

25 June 2020 - 24 August 2020

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

The determination was carried out by the flask method, using a procedure designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Specific details on test material used for the study:

Batch: 1000352370

Key result

Water solubility:

< 0.051 mg/L

Incubation duration:

> 24 - <= 72 h

Temp.:

20 °C

pH:

ca. 6

Details on results:

PRELIMINARY TEST
The preliminary estimate of the water solubility at 20.0 ± 0.5 °C was less than 5.27 x10^-5 g/L. The solution had a pH of 6.0.

MEAN CONCENTRATION
Less than 5.15 x 10^-5 g/L at 20.0 ± 0.5 ºC

DISCUSSION
On completion of the equilibration period, the samples were clear and colourless with excess, undissolved test item present. After filtration, the filtrates were visually observed to be clear, colourless, free from un-dissolved test item and with no definitive Tyndall beam effect.
The ion masses chosen for the analysis were used to represent the whole test item with it being a complex mixture and monitoring all components would not be practical; they were chosen from significant masses present in the mass spectrum of the test item.
The standard at 1.03 mg/L was excluded from calibration curve as it was considered to be inconsistent with the other standards and significantly affected the correlation. As the samples and matrix blank peak areas were less than that of the lowest standard, not including the 1.03 mg/L standard was considered to have no effect.
The sample and matrix blank generated very similar chromatograms. It was not confirmed if this was from the blank being contaminated or a background response. A fresh aliquot of the matrix blank was subsequently re-injected and still had similar chromatography so confirmed sample mix-up wasn’t the cause. The mass spectrum of the main peaks was like that of the mass spectrum of the corresponding peaks in the standards. Even so, the total peak area of the samples was less than that of the least concentrated standard (5.15 x 10^-5 g/L) and therefore, the results were reported as limit values based on the concentration of this standard. It is also noted that the preliminary test matrix blank and sample had chromatograms with significantly smaller peaks than those of the definitive test.

Conclusions:

The water solubility of the test item has been determined to be less than 5.15 x 10-5 g/L of solution at 20.0 ± 0.5 °C.

Executive summary:

The determination was carried out by the flask method, using a procedure designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

Description of key information

The water solubility of the test item has been determined to be less than 5.15 x 10-5 g/L of solution at 20.0 ± 0.5 °C.

Key value for chemical safety assessment

Water solubility:

0.051 mg/L

at the temperature of:

20 °C

Additional information

The water solubility of the test item has been determined to be less than 5.15 x 10-5 g/L of solution at 20.0 ± 0.5 °C.