Registration Dossier
Registration Dossier
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EC number: 220-168-0 | CAS number: 2650-18-2
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vitro / ex vivo
- Type of information:
- other: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Remarks:
- The study is conducted on a read across test material. The complete read across justification is attached in section 13. The reliability of the original study is 4.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Draft OECD Guideline (1996)
- Principles of method if other than guideline:
- Percutaneous absorption in vitro (400 – 900 μm thickness skin from porcine ears)
Test material
- Reference substance name:
- Similar Substance 1
- IUPAC Name:
- Similar Substance 1
Constituent 1
Results and discussion
- Total recovery:
- The mean recovery was 93.3% ± 4.05% (SD) in experiment I, and 115,2% ± 6.43% (SD) in experiment II.
Percutaneous absorption
- Time point:
- 24 h
- Dose:
- 5 mg
- Remarks on result:
- other: No absorption observed
Any other information on results incl. tables
Any measurable permeation through skin was not detected (Limit of detection: 5.5 - 5.7 μg/cm2 in
the two experiments, equivalent to 0.09-0.12% of the applied total amount.)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
