Registration Dossier
Registration Dossier
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EC number: 821-997-6 | CAS number: 2136366-99-7
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
No experimental toxicokinetic study is available on the registered substance. However, as per REACH guidance document R7.C, information on absorption, distribution, metabolism and excretion may be deduced from the physicochemical properties.
Based on the toxicological data and the physicochemical properties, the absorption of the registered substance is expected by oral route, dermal route and inhalation.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 100
- Absorption rate - inhalation (%):
- 100
Additional information
No experimental toxicokinetic study is available on the registered substance. However, as per REACH guidance document R7.C, information on absorption, distribution, metabolism and excretion may be deduced from the physicochemical properties, including:
-Mean molecular weight: 212.25 g/mol
-Water solubility: 381.6 mg/L (20°C) (moderately soluble)
-Partition coefficient Log Kow: 3.58
-Vapour pressure: 14.7 Pa
ABSORPTION
The moderate values of log Kow (3.58) and water solubility (381.6 mg/L) of the registered substance are favorable for an oral absorption. However, no clinical effects or mortality were observed after one single administration (2000 mg/kg) of the registered substance by gavage (oral route) in rats.
With a solubility of 381.6 mg/L, dermal absorption is anticipated to be moderate to high. A Log Kow of 3.58 and the molecular weight of 212.25 g/mol are favourable to a dermal absorption. The acrylates are known to bind to skin components, and this binding decreases their dermal absorption. In the dermal acute toxicity study, where no major systemic effect or mortality were observed in rats treated with 2000 mg/kg bw. However, the registered substance is a strong skin sensitizer based on the LLNA performed.
Based on the moderate value of the vapour pressure, the registered substance, the absorption by inhalation can be expected.
DISTRIBUTION and METABOLISM
No specific data is available on the distribution or metabolism of the registered substance. No organ toxicity was showed in the studies.
ELIMINATION
Due to the moderate water solubility and the low molecular mass, the excretion of the registered substance in the urines is expected. An excretion via bile and faeces is also possible.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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