Registration Dossier
Registration Dossier
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EC number: 200-896-5 | CAS number: 75-73-0
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption, other
- Remarks:
- predicted dermal absorption
- Type of information:
- (Q)SAR
- Remarks:
- prediction by EPIsuite
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
Data source
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Prediction by EPIsuite
- GLP compliance:
- not specified
Results and discussion
Percutaneous absorption
- Key result
- Parameter:
- percentage
- Absorption:
- ca. 10 %
Applicant's summary and conclusion
- Conclusions:
- Based on the physico-chemical properties of tetrafluoromethane (MW = 88.003 g/mol, log Kow = 1.18, water solubility = 18.8 mg/L), skin absorption is expected to be 10%.
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