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EC number: 229-029-9 | CAS number: 6406-56-0
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- Ecotoxicological Summary
- Aquatic toxicity
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- Short-term toxicity to fish
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Endpoint summary
Administrative data
Description of key information
Bioaccumulation: aquatic /sediment:
Using BCFBAF Program (v3.00) model of EPI suite 2017 the estimated bio concentration factor (BCF) for sodium 4-({4-[(2-hydroxy-1-naphthyl)diazenyl]phenyl}diazenyl)benzenesulfonate (CAS No.6406-56-0) is 3.162 L/kg wet-wt at 25 deg. c which does not exceed the bioconcentration threshold of 2000. Therefore it is concluded that test chemical sodium 4-({4-[(2-hydroxy-1-naphthyl)diazenyl]phenyl}diazenyl)benzenesulfonate is non bioaccumulative in food chain.
Additional information
Bioaccumulation: aquatic /sediment:
Predicted data for target chemical sodium 4-({4-[(2-hydroxy-1-naphthyl)diazenyl]phenyl}diazenyl)benzenesulfonate (CAS No.6406-56-0) and supporting weight if evidence study for its read across chemical have been studied and their results are summarized below.
The first weight of evidence study was done by Using BCFBAF Program (v3.00) model of Estimation Program Interface (EPI suite 2017) in this study the estimated bio concentration factor (BCF) for sodium 4-({4-[(2-hydroxy-1-naphthyl)diazenyl]phenyl}diazenyl)benzenesulfonate (CAS No.6406-56-0) is 3.162 L/kg wet-wt at 25 deg. c which does not exceed the bioconcentration threshold of 2000.
Next weight of evidence study was done by using Bio-concentration Factor (v12.1.0.50374) module of Advanced Chemistry Development (ACD) / I lab predictive module in this study the Bio-concentration Factor at range pH 3-14 of the chemical sodium 4-({4-[(2-hydroxy-1-naphthyl)diazenyl]phenyl}diazenyl)benzenesulfonate (CAS no.6406 -56 -0) estimated to be 1.0 dimensionless. This value indicates that the chemical sodium 4-({4-[(2-hydroxy-1-naphthyl)diazenyl]phenyl}diazenyl)benzenesulfonate is nonbioaccumulative in aquatic organisms as this value does not exceed 2000 criteria.
Next weight of evidence study was done from CompTox Chemistry Dashboard using OPERA (OPEn (quantitative) structure-activity Relationship Application) V1.02 model in which calculation based on PaDEL descriptors (calculate molecular descriptors and fingerprints of chemical) the bioaccumulation i.e BCF for test substance sodium 4-({4-[(2-hydroxy-1-naphthyl)diazenyl]phenyl}diazenyl)benzenesulfonate (CAS no.6406 -56 -0) was estimated to be 21.9 dimensionless . The predicted BCF result was based on the 5 OECD principles. Thus based on the result it is concluded that the test substance sodium 4-({4-[(2-hydroxy-1-naphthyl)diazenyl]phenyl}diazenyl)benzenesulfonate is non-bioaccumulative in nature, because the bioconcentration factor in fish is less than 2000.
Last weight of evidence study was done from authoritative database (HSDB, 2017) for structurally similar read cross chemical in this study the ionic character of read across disodium 6-hydroxy-5-[(4-sulfonatophenyl)diazenyl]naphthalene-2-sulfonate(CAS no. 2783-94-0) suggests the potential for bioconcentration in aquatic organisms is expected to be low.
On the basis of all the studies mentioned above it observed that BCF value was in range of 1- 21.9 dimensionless on the basis of this value it can be concluded that target chemical Sodium 4-(4-(2-hydroxynaphthalenylazo)phenylazo)benzenesulphonate (CAS no. 6406-56-0) is non bioaccumulative in nature as this range value is far less than 2000 criteria.
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