Registration Dossier
Registration Dossier
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EC number: 213-926-7 | CAS number: 1067-25-0
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- In this study the groups of 5 male and 5 female Charles River CD rats were exposed for 6 hours to 48.9 mg/L.
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Trimethoxypropylsilane
- EC Number:
- 213-926-7
- EC Name:
- Trimethoxypropylsilane
- Cas Number:
- 1067-25-0
- Molecular formula:
- C6H16O3Si
- IUPAC Name:
- trimethoxy(propyl)silane
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- TX-1499 (176 g/mol) in a cover sheeet identified as propyltrimethoxysilane, although the molecular weight of propyltrimethoxysilane is 164 g/mol.
Test animals
- Species:
- rat
- Strain:
- other: Charles River CD rats
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- ca. 6 h
- Concentrations:
- High dose level: 48.9 mg/L
- No. of animals per sex per dose:
- 5 female and 5 male
- Control animals:
- not specified
- Details on study design:
- 6 hours inhalation, 14 days observation period
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Remarks:
- surrogate LC50
- Effect level:
- ca. 48.9 mg/L air
- Based on:
- not specified
- Exp. duration:
- 6 h
- Remarks on result:
- other: mortality of 3 rats, poor documentation
- Mortality:
- 3 rats during the 14 days observation period
Applicant's summary and conclusion
- Interpretation of results:
- other: valid, but poor documented due to old standards of 1978
- Conclusions:
- LC50 for acute inhalation (6 hours inhalation, 14 days observation period) in rats = 48,9 mg/L
- Executive summary:
LC50 in this study = 48.9 mg/L
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