Registration Dossier
Registration Dossier
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Reaction mass of Tetrasodium 3-{[5-({4-[alkyl(3-{[2-(sulfonatooxy)ethyl]sulfonyl}phenyl)amino]-6-fluoro- heteromonocycle-2-yl}amino)-2-sulfonatophenyl]diazenyl}-4-hydroxy-5-(alkanoylamino)naphthalene-2,7-disulfonate and Trisodium 3-[{5-[(4-{[3-(ethenylsulfonyl)phenyl](alkyl)amino}-6-fluoro-heteromonocycle-2-yl)amino]-2-sulfonatophenyl}diazenyl]-4-hydroxy-5-(alkanoylamino)naphthalene-2,7-disulfonate
EC number: - | CAS number: -
Endpoint summary
Administrative data
Description of key information
Additional information
Aquatic acute tests covering 2 trophic levels, (algae and fish), were conducted. Activated sludge respiration inhibition data is also presented.
In accordance with column 2 of REACH Annex VIII-X, the acute Daphnia study does not need to be conducted if a long-term aquatic toxicity study on invertebrates is available (performed for China Level II notification; according to Guidance for New Chemical Substance Notification" (September, 2010)).
All the aquatic studies were conducted in accordance with GLP and OECD guidance and endpoints were based on nominal concentrations.
- In an OECD 203 acute fish toxicity test the 96 hour LC50 was found to be greater than 100 mg/L.
- The OECD 202 acute Daphnia magna test was not performed as a long-term aquatic toxicity study on invertebrates is available (performed for China Level II notification; according to Guidance for New Chemical Substance Notification" (September, 2010)).
- In an OECD 211 Long-term toxicity to aquatic invertebrates, the 21-Day EC10 and EC50 (immobilization) values based on nominal concentrations, for the parental daphnia generation (P1) were calculated to be 15 and 37 mg/L respectively.
The 21-Day EC10 and EC50 (reproduction) values based on nominal concentrations were 19 and greater than 50 mg/L respectively.
The "Lowest Observed Effect Concentration" (LOEC) and the "No Observed Effect Concentration" (NOEC) based on nominal test concentrations were 50 and 25 mg/L respectively.
The "Maximum Acceptable Toxicant Concentration" (MATC) was calculated to be 35 mg/L.
- In an OECD 201 algal inhibition test the 72 hour ErC50 for growth rate was found to be greater tha 100 mg/L and the NOEC was found to be 56 mg/L.
- In an OECD 209 activated sludge respiration inhibition test the 3 hour EC50 was determined to be greater than 1000 mg/L
In conclusion there is no indication of toxicity of FAT 40870/A TE to the aquatic environment.
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