L-Ascorbic acid, 3-O-ethyl-

Vapour pressure

Administrative data

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2016

Report date:

2016

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Test guideline 3

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7950 (Vapor Pressure)

GLP compliance:

yes

Type of method:

effusion method: by loss of weight or by trapping vaporisate

Test material

Test material information

Constituent 1

Reference substance name:

(5R)-5-[(1S)-1,2-dihydroxyethyl]-4-ethoxy-3-hydroxy-2,5-dihydrofuran-2-one

EC Number:

617-849-3

Cas Number:

86404-04-8

Molecular formula:

C8H12O6

IUPAC Name:

(5R)-5-[(1S)-1,2-dihydroxyethyl]-4-ethoxy-3-hydroxy-2,5-dihydrofuran-2-one

Details on test material:

Name of test material (as cited in study report): Ethyl Ascorbic acid
Physical state: White to very pale yellow crystalline powder
Test item storage: In freezer (≤ -15°C) desiccated
Stability: Stable under storage conditions until 21 April 2018 (retest date)

Results and discussion

Vapour pressure

Vapour pressure 1

Temp.:

20 °C

Vapour pressure:

<= 0 Pa

Vapour pressure 2

Temp.:

25 °C

Vapour pressure:

<= 0 Pa

Any other information on results incl. tables

Results

The results of the isothermal TGA analysis for the test item and the vapour pressure at 20 °C and 25 °C are given in Tables 1 and 2.

Table 1: Results of the isothermal TGA analysis

Temperature [°C]	Weight loss [μg/min]	VT [g/cm^2/h]	log VT	log PT	PT [Pa]
140	3.065	3.66E-04	-3.44	0.63	4.3
	4.169	4.98E-04	-3.30	0.73	6.1
150	7.997	9.55E-04	-3.02	1.11	13
	8.769	1.05E-03	-2.98	1.15	14
160	17.44	2.08E-03	-2.68	1.49	31
	18.34	2.19E-03	-2.66	1.52	33
170	34.93	4.17E-03	-2.38	1.84	69
	35.69	4.26E-03	-2.37	1.85	70

 

Table 2: Vapour pressure of the test item

Temperature [°C]	log PT	PT[Pa]	PT[mmHg]
20	-6.15	7.1E-07	5.3E-09
25	-5.75	1.8E-06	1.3E-08

 

Conclusion

The isothermal TGA effusion method was applied for the determination of the vapour pressure of Ethyl Ascorbic acid. The weight losses of the test item were obtained at temperatures above the melting temperature of the test item because no significant weight loss of the test item was observed below the melting temperature. According to this, the vapour pressure at 20°C and 25°C might be overestimated.

The vapour pressure of the test item at 20 °C (293K) and 25 °C (298K) was therefore reported as equal or less than values.

 

	20 °C		25 °C
	[Pa]	[mmHg]	[Pa]	[mmHg]
Test item	<7.1-07	<5.3E-09	<1.8E-06	<1.3E-08