Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 221-130-6 | CAS number: 3010-02-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- prior to GLP and OECD TG
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- prior to GLP and OECD TG
- Principles of method if other than guideline:
- According to BASF-internal standard.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- (diethylamino)acetonitrile
- EC Number:
- 221-130-6
- EC Name:
- (diethylamino)acetonitrile
- Cas Number:
- 3010-02-4
- Molecular formula:
- C6H12N2
- IUPAC Name:
- 2-(diethylamino)acetonitrile
- Details on test material:
- Name of the test substance used in the study report: Produkt 73/127 dest. (= Diaethylaminoacetonitril dest.)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- 2 of the animals were purchased and 1 animal was bred.
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The substance was applied on the back. Application area: 50 cm2.
- Doses:
- 0.2 mL undiluted test substance
- No. of animals per sex per dose:
- 3
- Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- < 174 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: original value: < 0.2 mL/kg
- Sex:
- male/female
- Dose descriptor:
- LD100
- Effect level:
- <= 174 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: original value: < 0.2 mL/kg
- Mortality:
- Two animals died within 25 minutes. The third animal died after about 50 minutes.
- Clinical signs:
- After about 10 minutes in all three animals rapid breathing was observed. Shortness of breath was observed after another 10 minutes togerther with crying and severe apathy.
- Gross pathology:
- heart: acute dilatation and congestive hyperemia; lung: slightly edematised
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 based on GHS criteria
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
