Registration Dossier
Registration Dossier
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EC number: 202-869-3 | CAS number: 100-60-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 961
- Report date:
- 1961
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Details on test material:
- Name of the test substance used in the study report: N-Monomethylcyclohexylamin
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- The test substance was administered in concentrations of 2, 8 or 20% (v/v) (aqueous suspension with Traganth).
- Doses:
- 171, 342, 428, 548, 685, 1369 mg/kg
- No. of animals per sex per dose:
- 5 per doxe
- Details on study design:
- - Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- approximate LD50
- Effect level:
- ca. 428 mg/kg bw
- Sex:
- male/female
- Dose descriptor:
- approximate LD50
- Effect level:
- ca. 500 other: cmm/kg
- Remarks on result:
- other: original value
- Mortality:
- 171 mg/kg: no deaths after 7 days; 342 mg/kg; 1/5 after 7 days; 428 mg/kg: 2/5 after 7 days; 548, 685 and 1369 mg/kg: 5/5 after 7 days
- Clinical signs:
- restlessness, excitation, partly long-lasting tonic-clonic spasms
- Gross pathology:
- inflammation of the gastrointestinal duct
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
