Registration Dossier
Registration Dossier
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EC number: 293-003-3 | CAS number: 91031-98-0
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects up to the limit of water solubility for Danio rerio (ISO 7346-1, read across)
Key value for chemical safety assessment
Additional information
Since no study investigating the short-term toxicity of Fatty acids, C8 -10, octyl esters (CAS 91031-98-0) to fish is available, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 Grouping of substances, read-across to the structurally similar substance hexyl dodecanoate (CAS 34316-64-8) was conducted. Further justification of the read-across approach is given within the endpoint summary 6.1 and the analogue justification document in section 13.
The key study conducted with hexyl dodecanoate (CAS 34316-64-8) was performed according to the guideline ISO 7346-1 (similar to OECD 203) under semi-static conditions, using Danio rerio as test organism (Guhl and Mühlberg, 2005). The fish were exposed to nominal test concentrations of 100, 300, 700, 1000, 3000 and 10000 mg/L during 96 hours. Significant mortality occurred at the two highest test concentrations, and an LC50 of 2200 mg/L was derived. However, the test concentrations in this study were far above the saturation limit of the test substance, and undissolved test material was not removed from the test solutions. The sudden increase in mortality from 0% at concentrations 100 – 1000 mg/L to 70% at 3000 mg/L is better explained by a physical effect, caused by the amount of undissolved material in the test solution, rather than a systemic toxic effect. It is therefore indicated that no toxic effects occurred up to the limit of water solubility of the test substance.
Based on this result and due to the structural and profile similarities of the target and the source substance, it can be concluded that no toxicological short-term effects on freshwater fish are expected up to the limit of water solubility for Fatty acids, C8-10, octyl esters (CAS 91031-98-0).
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