2,2'-iminodi(ethylamine)

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Not applicable

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The study was conducted according to guideline and/or standard method but was non-GLP. Meets basic scientific principles.

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1977

Report date:

1977

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

Rats are orally gavaged and observed for 14 days.

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2,2'-iminodi(ethylamine)

EC Number:

203-865-4

EC Name:

2,2'-iminodi(ethylamine)

Cas Number:

111-40-0

Molecular formula:

C4H13N3

IUPAC Name:

bis(2-aminoethyl)amine

Details on test material:

- Name of test material (as cited in study report): Diethylenetriamine

Test animals

Species:

rat

Strain:

Wistar

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: reared in our own colony
- Age at study initiation: 3 to 4 weeks
- Weight at study initiation: 90-120 grams
- Fasting period before study: no

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Details on oral exposure:

Test material was delivered undiluted by oral gavage.

Doses:

1.0, 2.0 and 4.0 ml/kg

No. of animals per sex per dose:

Five

Control animals:

no

Details on study design:

No data

Statistics:

No data

Results and discussion

Preliminary study:

No data

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

1.62 mL/kg bw

Remarks on result:

other: 1.18 to 2.24 ml/kg range

Mortality:

4.0 ml/kg: 5/5 dead - Days to Death 0, 0, 1, 1, 1
2.0 ml/kg: 4/4 dead - Days to Death 2, 3, 7, 8

Clinical signs:

other: 4.0 ml/kg; Sluggish 2 min; prostrate 3 hr; death of 2 at 4 hour 2.0 ml/kg: Sluggish 10 min

Gross pathology:

In victims, petechial hemorrhages of the lungs; stomachs liquid filled, hemorrhaged; intestines liquid-filled, opaque, hemorrhaged, slightly yellow; kidneys and adrenals slightly congested; kidneys speckled; livers and spleens mottled. Nothing remarkable in survivors.

Other findings:

No data

Any other information on results incl. tables

Diethylenetriamine was moderately toxic following single stomach intubation.

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Remarks:

Migrated information

Conclusions:

The acute oral LD50 of DETA in rats is 1.62 ml/kg (using the density value of 958.6 kg/m3 (IUCLID section 4.4), this corresponds to 1553 mg/kg).

Executive summary:

The acute oral toxicity of DETA was examined in rats. The acute oral LD50 of DETA in rats is 1.62 ml/kg. Using the density value of 958.6 kg/m³ (IUCLID section 4.4), this corresponds to 1553 mg/kg.