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Description of key information

The toxicokinetic assessment of NaDMH is based on a weight of evidence approach and prepared based on the physico-chemical and toxicological studies being also part of this registration.
Methyl acetotacetate (MAA), CAS 105-45-3 is a small, mobile, relatively volatile and uncharged molecule with excellent solubility in hydrophilic and hydrophobic solvents. It is rapidly and almost completely absorbed after oral exposure. Absorption via the dermis is comparatively lower which may also be due to the volatile behavior. MAA is rapidly excreted after hydrolysis of the ester function and also rapidly eliminated during metabolism. Tests with repeated dose administration demonstrate that outside lethal doses the effects of MAA are completely reversible. Cumulation in the body can be excluded.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

The NaDMH toxicokinetic assessment is based on a weight of evidence approach.