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Diss Factsheets
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EC number: 931-203-0 | CAS number: 1335202-88-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Human data from two different types of skin irritating test methods (24 hour occlusive application and 30 minute open application) are available for
partially unsaturated TEA-Esterquat, including the results from a total of 100 volunteers.
Information from two Human Repeated Insult Patch Tests evaluating the skin sensitisation of TEA-Esterquats is available. There was no evidence
for a skin sensitisation potential from this studies involving a total of 208 volunteers.
Additional information
Skin irritation
In three studies, a total of 60 panellists were exposed to 1 to 10 % solutions of partially unsaturated TEA-Esterquat for 24 hours under occlusive conditions. Slight and transient irritation indicated by the occurrence of erythema was observed in 5 of 60 panellists. In one of the studies applying a 5 % test substance dilution a skin irritation comparable to the water control was observed. Most likely this is the result of the extended 24-hour exposure and occlusive conditions.
Two 30-minute open application studies conducted with a total of 40 volunteers, which were exposed to 10 % aqueous solutions of partially unsaturated TEA-Esterquat, revealed no evidence of a skin irritation response in humans. (However, a quickly disappearing slight erythema was observed in two panellists.)
Conclusion
Human open application tests, reflecting more realistically the type of exposure humans are experiencing when using partially unsaturated TEA-Esterquat, showed a very favorable skin compatibility profile indicated by an absence of a skin irritation response. Even under more severe exposure conditions such as 24-hrs occluded patch tests, the exposure to partially unsaturated TEA-Esterquats in concentrations up to 10 % resulted in only mild and transient skin irritation, in some of thepanellists.
Sensitisation
The human volunteer studies were conducted in line with the respective and broadly accepted testing protocol according to the method of Stotts (1980) under the supervision of expert dermatologists.
None of the 2 studies involving exposures of a total of 208 human volunteers to fully saturated TEA-Esterquat was considered to induce a skin sensitisation response in humans.
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