Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-312-7 | CAS number: 105-59-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- BASF-Test. The study was conducted according to an internal BASF method which in principle is comparable to the OECD Guideline 401.
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- 2,2'-methyliminodiethanol
- EC Number:
- 203-312-7
- EC Name:
- 2,2'-methyliminodiethanol
- Cas Number:
- 105-59-9
- Molecular formula:
- C5H13NO2
- IUPAC Name:
- 2-[(2-hydroxyethyl)(methyl)amino]ethan-1-ol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: male: 180 - 260 g; female: 144 - 210 g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 200, 1600, 3200, 4000, 5000, 6400 mL/kg bw (208, 1664, 3328, 4160, 5200, 6656 mg/kg bw; conversion into mg/kg is based on the density d= 1.04 g/cm3 -according to BASF internal data)
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Details on study design:
- A test group consisting of 10 animals/sex was treated by single gavage application with an aqueous solution of the test substance. The animals were observed for mortality and for clinical symptoms of toxicity. At the end of the observation period of 7 days, the surviving animals were sacrificed for the purpose of necropsy; animals that died during the observation period also were subjected to necropsy.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 4 680 mg/kg bw
- Remarks on result:
- other: Conversion into mg/kg is based on the density d= 1.04 g/cm3
- Mortality:
- The test substance caused systemic toxicity including mortality in a dose dependent manner.
See details in remarks on results. - Clinical signs:
- other: 3328 - 6656 mg/kg bw: immediately squatting posture, ruffled fur and gasping. On the next day some animals showed bloody eyes and noses, ruffled fur and gasping. 1664 mg/kg bw: immediately squatting posute, ruffled fur and gasping.
- Gross pathology:
- Animals that died: all animals had smeared snouts and urogenital tracts. 11x droopy gastrointestinal tract with bloody content
Sacrificed animals: 8x bronchitis and bronchiectasis.
Any other information on results incl. tables
Mortality:
Dose (mg/kg bw) | Gender | Conc.(%) | 1 h | 24 h | 48 h | 7 days |
6656 | male | 30 | 0/10 | 7/10 | 7/10 | 7/10 |
6656 | female | 30 | 0/10 | 10/10 | 10/10 | 10/10 |
5200 | male | 30 | 0/10 | 3/10 | 3/10 | 3/10 |
5200 | female | 30 | 0/10 | 10/10 | 10/10 | 10/10 |
4160 | male | 30 | 0/10 | 2/10 | 2/10 | 2/10 |
4160 | female | 30 | 0/10 | 5/10 | 6/10 | 6/10 |
3328 | male | 30 | 0/10 | 1/10 | 1/10 | 1/10 |
3328 | female | 30 | 0/10 | 0/10 | 0/10 | 0/10 |
1664 | male | 20 | 0/10 | 0/10 | 0/10 | 0/10 |
1664 | female | 20 | 0/10 | 0/10 | 0/10 | 0/10 |
208 | male | 2 | 0/10 | 0/10 | 0/10 | 0/10 |
208 | female | 2 | 0/10 | 0/10 | 0/10 | 0/10 |
The test substance caused systemic toxicity including mortality in a dose dependent manner.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.