2,5-Dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenylamine

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1990

Report date:

1990

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Test type:

standard acute method

Limit test:

yes

Test material

Reference

Name:

Unnamed

Type:

Constituent

Details on test material:

- Test article: CGA 224443 tech.
- Batch No.: P. 810012
- Purity: 92,6%

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Ciba-Geigy Ltd. (Animal Production)
- Age at study initiation: 7 - 8 weeks
- Weight at study initiation: 212 - 237 g
- Fasting period before study:
- Housing: individually in Macrolon cages type 3, with standardized soft wood bedding
- Diet (e.g. ad libitum): NAFAG 890 Tox and water
- Acclimation period: 5 days


ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 2
- Humidity (%): 55 +/- 10
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12 / 12

Administration / exposure

Type of coverage:

semiocclusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

PRETREATMENT
Approximately 24 hours before treatment an area on the back of the rat of at least 10% of the bodysurface was shaved with an electric clipper.

APPLICATION
The required amount of the test substance was evenly dispersed on the skin. It was covered with a gauze-lined semiocclusive dressing fastened around the trunk with an exposure period of 24 hours the dressing was removed and the skin was cleaned with lukewarm water. Thereafter the skin reaction was appraised repeatedly.

Duration of exposure:

24 hours

Doses:

One single dose
Dose level: 4000 mg/kg body weight

No. of animals per sex per dose:

dose group: 10 rats (5 males and 5 females)

Control animals:

no

Details on study design:

OBSERVATIONS AND RECORDS
- Observation period: 14 days
- Mortality: daily; a.m. and p.m. on working days, a.m. on weekend days
- Signs and symptoms: daily
- Body weight: immediately before application and on days 7 and 14
- Necropsies: The animals were submitted to a gross necropsy at the end of the observation period.

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 4 000 mg/kg bw

Mortality:

No mortality occured in this study

Clinical signs:

Piloerection, abnormal body positions and dyspnea were seen, being common symptoms in acute dermal tests.
The animals recoverd within 5 days.
See attached Table 2

Body weight:

see attached Table 1

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information