Registration Dossier
Registration Dossier
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EC number: 232-417-0 | CAS number: 8017-16-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Abstract only; insufficient number of animals tested, no information on test conditions and scope of investigation per animal
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Orthophosphoric acid
- EC Number:
- 231-633-2
- EC Name:
- Orthophosphoric acid
- Cas Number:
- 7664-38-2
- Molecular formula:
- H3O4P
- IUPAC Name:
- phosphoric acid
- Details on test material:
- -Name: Orthophosphoric acid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Administration / exposure
- Type of coverage:
- semiocclusive
- Duration of exposure:
- 24 hours
- Doses:
- 631-7490 mg/kg bw
- No. of animals per sex per dose:
- 1 or 2/dose (no info on gender)
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 1 260 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 85% aqueous solution of phosphoric acid
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 3 160 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 80% aqueous solution of phosphoric acid
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 3 160 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 75% aqueous solution of phosphoric acid
Any other information on results incl. tables
Clinical signs included reduced appetite and activity, increasing weakness, collapse and death. Viscera of surviving animals appeared normal at autopsy
Applicant's summary and conclusion
- Interpretation of results:
- other: The reported LD50 values for 85, 80 and 75% aqeous solution of phosphoric acid were >1260, >3160 and >3160 mg/kg bw, respectively.
- Remarks:
- Criteria used for interpretation of results: not specified
- Conclusions:
- The reported LD50 values for 85, 80 and 75% aqeous solution of phosphoric acid were >1260, >3160 and >3160 mg/kg bw, respectively.
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