Registration Dossier
Registration Dossier
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EC number: 213-635-5 | CAS number: 996-35-0
Specific investigations: other studies
Administrative data
Link to relevant study record(s)
Description of key information
N,N-dimethylisopropylamine is irritating for the respiratory tract. The atmosphere concentration of N,N-dimethylisopropylamine which reduces the respiratory rate by 50% (RD50) was determined to be 90 (80-100) ppm in mice after a 15-minute exposure.
Additional information
The nasal irritation produced by N,N-dimethylisopropylamine was studied using male Swiss OF1mice (Gagnaire et al., 1989). Groups of six mice each were exposed to concentrations of N,N-dimethylisopropylamine ranging from 38 to 285 ppm in air for 15 min to determine the concentration at which the respiratory rate was decreased by 50% (RD50). The head of each mouse was isolated in an inhalation chamber, and the breathing frequency was measured with a pressure transducer before and during the exposure period. The RD50for N,N-dimethylisopropylamine was 90 ppm, and maximal effects were observed within 0.5 to 1 min.
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