Registration Dossier
Registration Dossier
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EC number: 200-350-6 | CAS number: 57-83-0
Endpoint summary
Administrative data
Description of key information
Only limited information is available concerning acute toxicity of Progesterone. On basis of the low acute toxicity of progesterone after single parenteral administration and the known oral LD50 values for this group of steroidal compounds no risk of acute poisoning has to be assumed after single uptake of progesterone.
Key value for chemical safety assessment
Additional information
Animal Data
Test system |
Substance |
Application |
Test concentration |
Toxicity |
Reference |
Rat |
|
Intraperitoneal |
|
LD50=327 mg/kg |
Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan), vol -, pg 1183, 1995 |
Mouse |
|
Intravenous |
|
LDLo=100 mg/kg Convulsions or effect on seizure; ataxia dyspnea
|
Journal of Medicinal Chemistry, American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.6- 1963-, vol 11, pg 117, 1968 |
Rat |
|
Intraperitoneal |
1 mg/kg
|
TDLo Endocrine (estrogenic) |
Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-, vol 92, pg 368, 1988. |
Rat |
|
Intraperitoneal |
16 mg/kg
|
TDLo Behavioral (general anesthetic) |
Clinical Pharmacology and Therapeutics. American Society for Clinical Pharmacology and Therapeutics, St. Louis Mo Mosby-Year Book) V.1- 1960-, vol 14, pg 727, 1976 |
Rat |
|
Intraperitoneal |
20 mg/kg
|
TDLo Behavioral (alteration of classical conditioning) |
Neuropsychopharmacology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010) V.1- 1987-, vol 29, pg 1597, 2004. |
Rat |
|
Subcutaneous |
2.5 mg/kg |
TDLo Behavioral (Changes in psychophysiological tests); effects on fertility (mating performance) |
Hormones and Behavior. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1969-, vol 49, pg 105, 2006 |
Rat |
|
Intramuscular |
1 mg/kg |
TDLo Kidney, ureter, bladder (other changes in urine composition); nutritional and gross metabolic (changes in Na) |
European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-, vol 454, pg 131, 2002 |
Mouse |
|
Intraperitoneal |
5 mg/kg |
TDLo Behavioral (change in motor activity, alteration of classical conditioning) |
Neuropsychopharmacology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010) V.1- 1987-, vol 23, pg 276, 2000 |
Justification for classification or non-classification
Based on the study results a classification according to Directive 67/548/EEC and Regulation (EC) 1272/2008 (CLP) is not required.
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