Registration Dossier
Registration Dossier
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EC number: 203-729-4 | CAS number: 110-02-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: 2a: Data from international report and study was performed according to OECD guideline without detail documentation.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- SIDS INITIAL ASSESSMENT PROFILE
- Author:
- OECD
- Year:
- 2 011
- Bibliographic source:
- UNEP publications
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Thiophene
- EC Number:
- 203-729-4
- EC Name:
- Thiophene
- Cas Number:
- 110-02-1
- Molecular formula:
- C4H4S
- IUPAC Name:
- thiophene
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Albino
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- other: closely clipped on the intact skin
- Vehicle:
- unchanged (no vehicle)
- Details on study design:
- Single doses of the undiluted test material were applied to the closely clipped, intact skin of albino rabbits.
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LDLo
- Effect level:
- > 3 160 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Conclusions:
- The dermal LDL0 was determined to be >3160 mg/kg after single doses of the undiluted test material applied to the closely clipped, intact skin of albino rabbits.
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