(6R,7R)-3-[(5-amino-4-{[(2-aminoethyl)carbamoyl]amino}-1-methyl-1H-pyrazol-2-ium-2-yl)methyl]-7-{[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate trifluoroacetate (1:3)

Guidance on Safe Use

First-aid measures

Do not induce vomiting. Rinse mouth and call the Poison Control Centre. Do not attempt to give any solid or liquid by mouth if the exposed subject is unconscious or semi-unconscious.

Move to fresh air and monitoring breathing. If breathing becomes difficult or ceases, give oxygen and activate the emergency.

Remove contaminated clothing and replace them with clean and dry ones. Wash the exposed skin area immediately with mild soap and water. Seek medical attention in case of irritation.

Wash out with fresh running water for at least 15 minutes. Ensure complete irrigation of the eyes by keeping eyelids well open. Consult a doctor.

Fire-fighting measures

Water, dry chemical, carbon dioxide (CO2), foam.

When heated the substance emits Carbon Oxides (COx), Nitrogen Oxides (NOx) and sulfur compound.

Use water spray for cooling exposed containers.

Do not enter fire area without proper protective equipment, including respiratory protection.

Accidental release measures

Avoid inhalation and contact with eyes and skin.

Alert Emergency Responders and tell them location and nature of hazard.

Avoid inhalation and contact with eyes and skin. Wear approved respiratory protection, chemically compatible gloves and protective clothing and safety glasses.

MINOR SPILLS

Clean up all spills immediately.

Use dry clean up procedures and avoid generating dust.

Avoid spillage of the product in water and sewage systems. Use rugs cover manholes, bags of absorbent material.

Avoid raising dust during collection and eliminate any source of ignition. Ventilate area and wash areas affected only after completing the collection of material. Avoid the use of oxidizing agents to wash the affected areas.

Sweep up or vacuum up.

Place spilled material in clean, dry, suitable, labeled container

MAJOR SPILLS

Control personal contact by using protective equipment and dust respirator.

Prevent spillage from entering drains, sewers or water courses.

Avoid generating dust.

Recover product wherever possible.

Put residues in labeled plastic bags or other containers for disposal.

If contamination of drains or waterways occurs, advise emergency services.

- Eye protection:

Must wear proper eye protection.

- Skin protection:

Tyvek coverall, safety shoes, gloves, forearm.

- Respiratory system protection:

Filter system FFP2.

Attention: for the choice of the material, take into consideration the possible individual allergic reactions.

Handling and storage

Measures to prevent fire

Use procedures to put equipment on the ground. Avoid static discharges accumulation. Protect form heat and direct sunlight.

Measures to prevent aerosol and dust generation

Handle taking care to close the trunk. The work environment must be provided with adequate ventilation systems or collection of gases and vapors that can be formed when handling.

Measures to protect the environment

Keep away from drains.

Advice on general occupational hygiene

Don’t eat, drink and smoke in work areas.

Wash hands after use.

Remove contaminated clothing and protective equipment before entering eating areas.

Store at temperature of <25 °C.

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:

NA

Shipping

SpecialProvisions

Inland waterway transport (UN RTDG/ADN(R))

UN number:

NA

Shipping

Remarks

Marine transport (UN RTDG/IMDG)

UN number:

NA

Shipping

Remarks

Air transport (UN RTDG/ICAO/IATA)

UN number:

NA

Shipping

Remarks

SpecialProvisions

Exposure controls / personal protection

Occupational Exposure limit values

N.D.

Appropriate Engineering controls

Analytical surveys are conducted to assess the concentration of dust in the work environment.

Personal protection

- Eye protection:

Must wear proper eye protection.

- Skin protection:

Tyvek coverall, safety shoes, gloves, forearm.

- Respiratory system protection:

Filter system FFP3

Attention: for the choice of the material, take into consideration the possible individual allergic reactions.

Environmental Exposure Controls

N.D.

Stability and reactivity

Incompatibility and conditions to be avoided

Protect from moisture. Avoid accumulation of electrostatic charge.

Keep away from open flames, heat and direct lighting.

Store at temperature of <25 °C.

Stable under normal storage conditions

Decomposition temperature

DSC:

Dynamic in air: an important exothermic effect is observed (ΔH = - 400 J / g) around 85 °C with a peak at 200 °C.

Isotherm at 35 ° C for 18 hours: there were no macroscopic effects.

Dynamics in air: on the sample after isotherm: a slight endothermic effect is observed (DH = 14.45 J / g) at a temperature of 68 °C (perhaps caused by metilterbutiletere solvent with boiling point at 55 °C), with a peak at 76 °C; follows an important exothermic effect (DH = - 337 J / g) that is not shared from the endothermic one, with peak at about 205 ° C.

Viscosity

N.D.

Disposal considerations

Do not let the product go into the sewerage system. Dispose of it in compliance with the national rules in force. The contaminated packing can be destined for re-utilization after having made a proper cleaning and decontamination.

Product

Give non-recyclable solutions and the surplus to a licensed waste disposal company.

Solubilize or mix the product with a combustible solvent, then burn in an incinerator for chemicals equipped with post-combustion system and scrubber.

Contaminated containers

Dispose of unused product