Registration Dossier
Registration Dossier
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EC number: 204-363-8 | CAS number: 120-00-3
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Authoritative data base
- Title:
- Danish QSAR study for CAS No.: 120-00-3
- Author:
- Danish EPA Model
- Year:
- 2 012
- Bibliographic source:
- QSAR predictions by Danish Environmental Protection Agency (EPA)model powered by OASIS database:-Commercial
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Modelling database
- Principles of method if other than guideline:
- Ames mutagenicity. Multicase model.
Note: The four sub models were made using only positive Ames test results to discriminate between direct mutagens (–S9) / and mutagens requiring metabolic activation (+S9) frame-shifts, basepairs and potency (>10 x background). They may serendipitously give some Ames
POS/NEG information. - GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 4'-amino-2',5'-diethoxybenzanilide
- EC Number:
- 204-363-8
- EC Name:
- 4'-amino-2',5'-diethoxybenzanilide
- Cas Number:
- 120-00-3
- Molecular formula:
- C17H20N2O3
- IUPAC Name:
- 4'-amino-2',5'-diethoxybenzanilide
- Details on test material:
- - Name of test material: 4'-amino-2',5'-diethoxybenzanilide
- Substance type: Organic
- Physical state: Solid
- Molecular Formula: C17H20N2O3
- Molecular Weight: 300.35
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium, other:
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9
Results and discussion
Test results
- Species / strain:
- S. typhimurium, other:
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
Genetic Toxicity of 4'-amino-2',5'-diethoxybenzanilide in Salmonella typhimurium With & Without Metabolic activation is estimated to give negative gene toxicity result. - Executive summary:
Genetic Toxicity of 4'-amino-2',5'-diethoxybenzanilide in Salmonella typhimurium With & Without Metabolic activation is estimated to give negative gene toxicity result.
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