Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 255-911-8 | CAS number: 42613-21-8
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- start 05.08.1974, duration 26 weeks
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: basic data given
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 408 (Repeated Dose 90-Day Oral Toxicity Study in Rodents)
- Deviations:
- yes
- Remarks:
- exposure time 26 weeks
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 112926-00-8
- EC Number:
- 601-214-2
- Cas Number:
- 112926-00-8
- IUPAC Name:
- 112926-00-8
- Details on test material:
- - Name of test material (as cited in study report): Syloid R 244
- Physical state: white powder
- Lot/batch No.: QD06-86-438 and QD10-86-665
- Stability under test conditions: stable
- Storage condition of test material: room temperature, protecetd from light
Constituent 1
Test animals
- Species:
- rat
- Strain:
- CD-1
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- unchanged (no vehicle)
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 26 weeks
- Frequency of treatment:
- daily, seven days per week for 26 weeks
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 2.17-2.42, 7.95-8.98 g/kg bw and day
Basis:
nominal in diet
- No. of animals per sex per dose:
- 12
- Control animals:
- yes, plain diet
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- > 8 980 mg/kg bw/day (nominal)
- Sex:
- male/female
- Basis for effect level:
- other: see 'Remark'
- Remarks on result:
- not determinable
- Remarks:
- no NOAEL identified
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
The concentrations used did not show any toxic effects in the parameters examined.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
