3-chlorophenyl isocyanate

Endpoint summary

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion

Additional information:

No skin sensitisation data available.

Migrated from Short description of key information:
No skin sensitisation data available.

Respiratory sensitisation

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed (not sensitising)

Additional information:

In a lung sensitizing study 8 female guinea pigs/ group were induced 3 times intradermal with the test substance (application in peanut oil on day 0- 5%, day 2- 2% and day 4- 2%, in each case 100 µl, twice). The control animals received the vehicle peanut oil under identical test conditions. After a 2-weeks observation period (day 21 to day 24) a test substance challenge was performed (medium concentration: ca. 0.7 mg test substance/m³ air). During and after each challenge-exposition (ca. 30 minutes duration) reactions of the direct-type wer measured in all animals by measuring the breathing-frequency, the breathing-volume, the breathing-minute-volume, the inspiration and the expiration-time and the Peak Expiratory Flow. Thereafter the measurement of the breathing-frequency in appriximately 20 minutes took place, in order to observ also delayed reactions. At the end of the observation period all guinea pigs were killed and the weight of the blood-free lung was determined. Lung and trachea were examined histologically.

After the test substance challenge no specific breathing reaction was observed, which could lead to a lung sensitizing potential of the test substance. Several animals of both groups showed marginal changes of the breathing parameters, however these parameters were not in coherence to the primary irritation potential of the test substance. No evidence of diminuated breathing reactions were observed. The analysis of Lung weights showed no statistic signifficant increase of the absolute or relative lungweight in the test substance group. The histopathological examinations of trachea and lung showed no statistical signifficant increase of eosinophil granulocytes in the submucosa of the bronchia in comparison to the vehicle control group. No toxicological important reactions, due to immunulogical reactions could be seen. The substance therefore is not found to be sensitizing to the lung (Pauluhn/ Bayer, 1993).

According RL 1272/2008/EG (GHS) a classification as Skin Sens.1A (H 317: May cause an allergic skin reaction) is warranted, based on comparative analysis regarding other isocyanates isocyanates (p-isopropylphenylisocyanate_CAS 31027-31-3, n-butylisocyanante_CAS 111-36-4, 3,4-dichlorphenylisocyanante_CAS 102-36-3, 3,5-dichlorphenylisocyanate_CAS 28479-22-3, phenylisocyanate_CAS 103-71-9, trifluormethoxyphenylisocyanate_CAS 35037-73-1 are all strong sensitisers, classified as Skin Sens. 1A)

Migrated from Short description of key information:
In a lung sensitizing study in female guinea pigs no toxicological important reactions, due to immunulogical reactions could be seen. The substance therefore is not found to be sensitizing to the lung (Pauluhn/ Bayer, 1993).

Justification for classification or non-classification

No data concerning skin sensitisation are available. Due to the fact that the test substance is an isocyanat, it has to be classified as R43

(REACH Regulation, Classification and Labeling, Appendix VI).

According RL 1272/2008/EG (GHS) a classification as Skin Sens.1A (H 317: May cause an allergic skin reaction) is warranted, based on comparative analysis regarding other isocyanates isocyanates (p-isopropylphenylisocyanate_CAS 31027-31-3, n-butylisocyanante_CAS 111-36-4, 3,4-dichlorphenylisocyanante_CAS 102-36-3, 3,5-dichlorphenylisocyanate_CAS 28479-22-3, phenylisocyanate_CAS 103-71-9, trifluormethoxyphenylisocyanate_CAS 35037-73-1 are all strong sensitisers, classified as Skin Sens. 1A).

A negative lung sensitizing study in guinea pigs is available and therefore no classification in respiratory sensitisation is necessary.