Carbamic acid, (2-hydroxypropyl)-, compd. with 1-amino-2-propanol (1:1)

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: group entry

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Material on the substantiation of the maximum allowable concentrations of mono-, di-, and triisopropanolamine in the air of a work area

Author:

Burkatskaya EN

Year:

1986

Bibliographic source:

Gigiena Truda i Professional nye Zabolevarija 30, 46-48, 1986

Reference 2

Reference Type:

secondary source

Title:

1-Aminopropan-2-ol (Monoisopropanolamin, MIPA) CAS-Nr. 78-96-6

Author:

Ausschuss für Gefahrstoffe

Year:

2006

Bibliographic source:

BAuA - Begründungen zu Arbeitsplatzgrenzwerten, Technische Regeln für Gefahrstoffe, 1-Aminopropan-2-ol in TRGS 900; web-page

Reference 3

Reference Type:

publication

Title:

Range finding toxicity data: List IV

Author:

Smyth HF

Year:

1951

Bibliographic source:

Archives of Industrial Hygiene and Occupational Medicine 4, 119-122, 1951

Reference 4

Reference Type:

secondary source

Title:

2-Propanol, 1-amino-, CAS-No. 78-96-6; SIDS Initial Assessment Profile for SIAM 32, 2011-04-19; Investigated in a Category C1-13 Primary Amines

Author:

OECD SIDS

Year:

2011

Bibliographic source:

OECD SIDS documents (Chemicals Screening Information Dataset for High Volume Chemicals); Conclusions agreed; available via web-page

Reference 5

Reference Type:

study report

Title:

Unnamed

Year:

1965

Report date:

1965

Reference 6

Reference Type:

secondary source

Title:

Final Report on the Safety Assessment of Diisopropanolamine, Triisopropanolamine, Isopropanolamine, and Mixed isopropanolamine

Author:

JACT

Year:

1987

Bibliographic source:

Journal of the Americal College of Toxicology, Volume 6, No. 1, 53-76, 1987

Materials and methods

Principles of method if other than guideline:

old methods for acute oral toxicity testing

GLP compliance:

no

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

1-aminopropan-2-ol

EC Number:

201-162-7

EC Name:

1-aminopropan-2-ol

Cas Number:

78-96-6

IUPAC Name:

1-aminopropan-2-ol

Constituent 2

Reference substance name:

1-amino-2-propanol

IUPAC Name:

1-amino-2-propanol

Test animals

Species:

rat

Administration / exposure

Route of administration:

oral: unspecified

Results and discussion

Effect levels

Effect levels 1

Dose descriptor:

LD50

Effect level:

1 715 mg/kg bw

Remarks on result:

other: reduced body temperature, diarrhoea, drowsiness

Effect levels 2

Dose descriptor:

LD50

Effect level:

4 260 mg/kg bw

Effect levels 3

Dose descriptor:

LD50

Effect level:

2 813 mg/kg bw

Remarks on result:

other: aqueous solutions of 2, 20, and 30% were administered; clinical symptoms: agitation, staggering gait, dispnoea, convulsions; macroscopic signs: none

Effect levels 4

Sex:

male

Dose descriptor:

LD50

Effect level:

2 098 mg/kg bw

Remarks on result:

other: groups of 6 rats were given 500 to 3500 mg/kg bw of the test substance; all rats were lethargic and had diarrhea and rough hair coats; no treatment related effects were observed upon pathological examination at the end of the 2 week observation period.

Applicant's summary and conclusion

Executive summary:

Various early acute oral toxicity studies not performed under GLP in summary show an LD50 of > 2000 mg/kg bw for 1-amino-2-propanol in rats. Clinical signs were reported as e.g. diarrhea, rough hair coats and lethargic behaviour.