Registration Dossier
Registration Dossier
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EC number: 224-536-1 | CAS number: 4402-30-6
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
With high probability acutely not harmful to fish
Key value for chemical safety assessment
Additional information
The toxicity of 1,1'-(methylimino)dipropan-2 -ol (CAS 4402 -30 -6) to fish (Leuciscus idus) was tested closely to the Guideline DIN 38 412, June 1982. The test concentration were not analytically verified but are assumed stable based on the low biodegradation potential, the high water solubility, the low adsorption potential and the low Henry's Law constant.
The test solutions (100 to 1000 mg/L) were studied without pH-adjustment. The initial pH values (pH 8-7 to 9.4) were above the recommended pH range of 6.0 to 8.5 (OECD TG 203). After 24 h, only the highest tested concentration (1000 mg/L) was still outside the recommended pH range with a pH of 9.1. In order to determine the effect of the pH shift caused by the test substance, the highest test concentration was studied after pH adjustment (initial pH 7.4) in parallel.
The exposed fish at 100 and 215 mg/L showed no symptoms and mortality during the whole exposure period. At 464 mg/L fish showed symptoms like apathy and tumbling after 48 h. The first fish died after 48 h (n = 1). At 1000 mg/L (not pH-adjusted), all fish were dead after 24 h. Observed symptoms were apathy, tumbling, and a narcotic-like state. After pH-adjustment of the highest test solution (1000 mg/L), the fish showed no symptoms and no fish died. It can be concluded that the observed mortality and symptoms were due to pH effects and not caused by an inherent toxic effect of the substance.
Without pH-adjustment, the 96-h LC50 was determined to be ca. 460 mg/L. After pH-adjustment, the 96-h LC50 was greater than 1000 mg/L. It can be concluded that the test substance is with high probability acutely not harmful to aquatic organism.
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