Registration Dossier
Registration Dossier
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EC number: 203-526-0 | CAS number: 107-85-7
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Dermal absorption of primary amines may occur but the rate is presently not known. Severe local skin corrosion, but no systemic toxicity was seen in rats receiving isopentylamine at 2000 mg/kg bw (occlusive, 24 hr exposure duration). The relevance of dermal absorption is therefore unclear.
Key value for chemical safety assessment
Additional information
It is generally acknowledged that primary aliphatic amines including 3-methylbutylamine (or isoamylamine) are well absorbed from the gut and the respiratory tract, and the simple aliphatic amines can produce lethal effects by percutaneous absorption. The LD50 by this route is often the same as that for oral administration (Bingham 2000; Greim 1998).
Thus amines may be absorbed via all routes of exposure. However, only severe skin corrosion but no systemic toxicity was seen in an acute dermal toxicity rat study (OECD TG 402, under GLP conditions; 2000 mg/kg, 24 h exposure duration, 5 rats/sex) (Safepharm, 1985.Cf. section 7.2.3). The relevance of dermal absorption is therefore unclear.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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