Registration Dossier
Registration Dossier
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EC number: 685-281-3 | CAS number: 2624-17-1
Carcinogenicity
Administrative data
Description of key information
Experimental results from 2 year carcinogenicity studies in rats and mice (monosodium salt and monosodium monohydrate salt of cyanuric acid were non-oncogenic by the oral route).
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Study duration:
- chronic
- Quality of whole database:
- Study performed to GLP and equivalent to guideline (Klimisch 1).
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
In both studies, under the experimental conditions, there is no evidence of carcinogenic potential of the test material.
Additional information
Rats: 1. Experimental results obtained with the substance monosodium salt of cyanuric acid, monohydrate (NOAEL ca. 154 mg/kg bw/day, male and NOAEL ca. 266 mg/kg bw/day, female).
Mice: 2. Experimental results obtained with the substance monosodium salt of cyanuric acid (NOAEL ca. 1520 mg/kg bw/day, male and NOAEL ca. 1580 mg/kg bw/day, female).
Justification for selection of carcinogenicity via oral route endpoint:
Chronic data is available (rats and mice).
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