Registration Dossier
Registration Dossier
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EC number: 233-797-0 | CAS number: 10361-82-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicological and pharmacological effects of gadolinium and samarium chlorides
- Author:
- T. J. Haley, K. Raymond, N. Komesu, and H. C. Upham
- Year:
- 1 961
- Bibliographic source:
- Br J Pharmacol Chemother. 1961 December; 17(3): 526–532
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 434 (Acute Dermal Toxicity - Fixed Dose Procedure)
- GLP compliance:
- not specified
- Test type:
- fixed dose procedure
Test material
- Reference substance name:
- Samarium (III) chloride hexahydrate
- EC Number:
- 233-797-0
- EC Name:
- Samarium (III) chloride hexahydrate
- Cas Number:
- 10361-82-7
- Molecular formula:
- Cl3Sm
- IUPAC Name:
- samarium (III) chloride hexahydrate
- Details on test material:
- - purity 99%
Constituent 1
Test animals
- Species:
- rabbit
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The method of Draize, Woodward & Calvery (1944) was used to study skin irritation in rabbits.
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- other: no irritation occured
- Based on:
- test mat.
Any other information on results incl. tables
Direct application of samarium chloride crystals to intact rabbit skin produced no irritation within 24 hr and no delayed reaction after 72 hr. There was a very severe reaction by abraded skin resulting in the maximum irritation index of 8 within 24 hr. No change was observed within 72 hr, and within 7 days perforating ulcers 25 to 30 mm in diameter developed with penetration through the skin to the underlying muscle layers. Inasmuch as healing did not occur, the animals were killed at 14 days. The differences in response between intact and abraded skin may be related to the liberation of nascent hydrochloric acid by tissue fluids. |
Applicant's summary and conclusion
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