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EC number: 248-704-9 | CAS number: 27871-49-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Justification for type of information:
- For details and justification of read-across please refer to the report attached in IUCLID section 13.
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 2 200 mg/L
- 95% CI:
- >= 1 900 - <= 2 600
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 2 300 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Key result
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 320 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Details on results:
- - Exponential growth in the control: yes
- Observation of abnormalities: no
- Unusual cell shape: no
- Colour differences: no
- Flocculation: no
- Adherence to test vessels: no
- Aggregation of algal cells: no
- Other: Many bacteria were found in the cultures containing test substance at the end of the test.
- Any stimulation of growth found in any treatment: no
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: no
- Effect concentrations exceeding solubility of substance in test medium: no - Executive summary:
This information is used in a read-across approach in the assessment of the target substance. For justification of read-across please refer to the attached read-across report (see IUCLID section 13).
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Qualifier:
- according to guideline
- Guideline:
- other: ECHA guidance on information requirements and chemical safety assessment, chapter R.6: QSARs and grouping of chemicals
- Deviations:
- no
- GLP compliance:
- no
- Specific details on test material used for the study:
- SMILES: C(=O)(C(C)O)OC
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 368 mg/L
- Remarks on result:
- other: calculated
- Validity criteria fulfilled:
- yes
- Conclusions:
- The EC50 for methyl-(S)-lactate was estimated at 368 mg/L, showing low acute toxicity to algae, not fulfilling the CLP criterion for being classified as environmentally hazardous (≤100 mg/L).
- Executive summary:
For the determination of the acute toxicity to algae value the 'Leadscope Enterprise model for acute toxicity to microalgae (72 h growth inhibition, EC50)' as included in the Danish QSAR Database, has been applied. Based on the calculated 72-h EC50 value of 368 mg/L it can be concluded that methyl-(S)-lactate shows low acute toxicity to algae, not fulfilling the CLP criterion for being classified as environmentally hazardous (≤100 mg/L).
Referenceopen allclose all
Table1: Measured concentrations of ethyl (S)-lactate.
Nominal concentration [mg/L] |
Measured concentrations |
|||
start |
end |
|||
mg/L |
% of nominal |
mg/L |
% of nominal |
|
0 |
<1 |
|
<1 |
|
100 |
110 |
110 |
54 |
54 |
1000 |
870 |
87 |
850 |
85 |
3200 |
2970 |
93 |
3040 |
95 |
Average % of nominal concentration |
97 |
78 |
Table 2: Set of cell counts (1.0E+04 particles/mL, corrected for background)
Time [h] |
Nominal concentration [g/L] |
|||||||
0 |
0 |
0.10 |
0.32 |
0.58 |
1.0 |
1.8 |
3.2 |
|
0 |
0.9 |
1.0 |
0.9 |
0.9 |
1.0 |
0.9 |
1.0 |
1.0 |
24.5 |
5.9 |
5.8 |
5.7 |
5.5 |
4.8 |
5.1 |
4.3 |
3.5 |
49 |
34.7 |
32.4 |
33.7 |
32.2 |
28.2 |
27.9 |
21.9 |
13.3 |
71.5 |
191.5 |
175.7 |
208.1 |
230.2 |
164.0 |
219.0 |
183.3 |
23.4 |
Description of key information
The modelled EC50 value of methyl (S)-lactate is 368 mg/L.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 368 mg/L
Additional information
The EC50 value for the read-across substance ethyl-(S)-lactate is 2200 mg/L based on inhibition of the algal growth rate. Thus, the substance of scope is practically non-toxic to algae. Both the predicted (368 mg/L) and the experimental value are significantly higher than 100 mg/L, the effect concentration that would trigger classification under CLP.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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