Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 246-240-1 | CAS number: 24424-99-5
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
Test guideline
- Guideline:
- other: acute inhalation toxicity
- GLP compliance:
- yes
Test material
- Reference substance name:
- Di(tert-butyl) carbonate
- EC Number:
- 246-240-1
- EC Name:
- Di(tert-butyl) carbonate
- Cas Number:
- 24424-99-5
- Molecular formula:
- C10H18O5
- IUPAC Name:
- di-tert-butyl carbonate
Constituent 1
Test animals / tissue source
- Species:
- rat
- Strain:
- Sprague-Dawley
Test system
- Vehicle:
- other: vapour
- Amount / concentration applied:
- 80/120/180 mg/m3
- Duration of treatment / exposure:
- 4h
- Observation period (in vivo):
- 14d
- Number of animals or in vitro replicates:
- 30
Results and discussion
In vivo
Results
- Irritation parameter:
- other: number of rats with corneal opacity as percentage of total in the two highest dose groups (120 and 180 mg/m3/4h)
- Basis:
- mean
- Time point:
- other: 6 days
- Score:
- 30
- Max. score:
- 100
- Reversibility:
- not reversible
- Remarks on result:
- other: No corneal opacity was seen in the lowest dose group at 80 mg/m3/4h
Any other information on results incl. tables
See attached full study report
Applicant's summary and conclusion
- Interpretation of results:
- Category I
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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