Registration Dossier
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EC number: 274-764-0 | CAS number: 70693-32-2
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No effects up to the limit of water solubility for Daphnia magna (OECD 202); read-across
Key value for chemical safety assessment
Additional information
No studies are available on the toxicity of Decanoic acid, mixed esters with neopentyl glycol and octanoic acid (CAS No. 70693-32-2) to aquatic invertebrates. The assessment of short-term toxicity to aquatic invertebrates was, therefore, based on studies conducted with the structurally similar category members Fatty acids, C8-18 and C18-unsatd., esters with neopentyl glycol (CAS No. 85186-86-3) and Decanoic acid, ester with 2-ethyl-2-(hydroxymethyl)-1,3-propanediol octanoate (CAS No. 11138-60-6). This read across approach is in accordance with Regulation (EC) No 1907/2006, Annex XI, 1.5. Grouping of substance and read across approach. Further justification is given within the endpoint summary 6.1 and within the category justification in Section 13.
The key study conducted with Fatty acids, C8-18 and C18-unsatd., esters with neopentyl glycol (CAS No. 85186-86-3) was performed as a limit test according to OECD Guideline 202 and GLP, in a static system (Häner, 2007). The test organism Daphnia magna was exposed to the test substance at the nominal test concentration of 100 mg/L for 48 hours. The test solutions were prepared as water accommodated fractions (WAF). No immobilisation was observed during the study, and the EL50 was reported to be > 100 mg/L.
The key study conducted with Decanoic acid, ester with 2-ethyl-2-(hydroxymethyl)-1,3-propanediol octanoate (CAS No. 11138-60-6) was performed as a limit test according to OECD Guideline 202, in a static system (Häner, 2007). The test organism Daphnia magna was exposed to the test substance at the nominal test concentration of 100 mg/L for 48 hours. The test solutions were prepared as water accommodated fractions (WAF). No significant immobilisation was observed during the study, and the EL50 was reported to be > 100 mg/L.
Thus, based on the above mentioned result, and due to the structural and profile similarities of the substances, as are explained with in the overall endpoint summary 6.1 it can be concluded that no short-term effects on aquatic invertebrates are expected up to the limit of water solubility for Decanoic acid, mixed esters with neopentyl glycol and octanoic acid.
As it can be seen in the data matrix of the category justification in section 13 and the overall endpoint summary IUCLID 6.1, all reliable data in the category support the hazard assessment of each category member by showing a consistent pattern of results, i.e. no toxic effects up to the limit of water solubility.
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