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Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

HPLC method

Partition coefficient type:

octanol-water

Specific details on test material used for the study:

Batch/Lot number: 381890
Purity: 99.8%

Analytical method:

high-performance liquid chromatography

Key result

Type:

log Pow

Partition coefficient:

<= 1

Temp.:

25 °C

pH:

7

Details on results:

Under the above detailed chromatographic conditions, applying the environmentally relevant pH = 7, the test item has a log Pow ≤ 1.0. The test item is considered to be non-ionised at pH 7; at pH 3 the test item was considered to be in an ionised form and had a lower log Pow, also presented as < 1.0. There were no other detected components (impurities) of the test item.

Conclusions:

The test item has a log Pow ≤ 1.0.

Executive summary:

The partition coefficient (log Pow) of the test substance was estimated using a High Performance Liquid Chromatographic method. This method is suitable for the log Pow estimation in case of the proper UV absorbance and retention under normal conditions.
Based on the retention times, the estimated log Pow value of the test item was ≤ 1.0, under the detailed chromatographic conditions in this report, where the test item was considered to be in its non-ionised form, applying the environmentally relevant pH = 7.

Description of key information

The test item has a log Pow ≤ 1.0.

Key value for chemical safety assessment

Log Kow (Log Pow):

1

at the temperature of:

25 °C