Registration Dossier
Registration Dossier
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EC number: 209-533-5 | CAS number: 584-13-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Toxikologičeskaja charakteristika novych inhibitorov nitrifikacii
- Author:
- C.B. Posocjan et all
- Year:
- 1 998
- Bibliographic source:
- Gigiena i Sanitariya (Hygiene and sanitation), 53(9), p. 83 (1988)
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Not specified
- Version / remarks:
- 1987
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 4H-1,2,4-triazol-4-ylamine
- EC Number:
- 209-533-5
- EC Name:
- 4H-1,2,4-triazol-4-ylamine
- Cas Number:
- 584-13-4
- Molecular formula:
- C2H4N4
- IUPAC Name:
- 4H-1,2,4-triazol-4-ylamine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Doses:
- 13620 mg/kg
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: days
Results and discussion
- Preliminary study:
- The selection of dose 2g/kg bw was based on orientative dose finding study.
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- not specified
- Mortality:
- mortality observed
- Clinical signs:
- other: Clinical signs: in acute intoxication, animal death occurred (in a dose-dependent manner) 2-3 days after administration
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- After a single oral administration (gavage) of the test substance to laboratory rats (> 2g/kg bw) signs of intoxication were detected by clinical examination. The clinical picture of acute toxicity in rats is mostly related to CNS disorders and is characterized by short-term irritation with a gradual transition to lethargy. Disruption of movement coordination was observed.
Single oral administration - LD50 13600 ± 1159 mg / kg (oral, rat)
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