Registration Dossier
Registration Dossier
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EC number: 835-656-4 | CAS number: 399017-10-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02/06/2000-12/09/2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- other: Good laboratory practice for Chemical Substances
- GLP compliance:
- yes
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- Ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate hydrochloride (1:1)
- EC Number:
- 835-656-4
- Cas Number:
- 399017-10-8
- Molecular formula:
- C13H14ClNO3S
- IUPAC Name:
- Ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate hydrochloride (1:1)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- methylcellulose
- Control animals:
- yes
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Gross pathology:
- The organs and tissues in the animals of both sexes did not show any abnormal signs in pathological examination.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- It is consiedered that the LD50 for Thiazole Derivative by gavage is over 2000 mg/kg in the rat, though the test article caused mastication-like repetitive movement of the jaw followed by staggering gait.
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