Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 930-930-0 | CAS number: -
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 4 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Additional information - workers
Calcium peroxide when in contact with water, on the one hand hydrolyses into hydrogen peroxide, and on the other hand results in a loss of active oxygen.
CaO2 + H2O → CaO + H2O2
2CaO2 → 2CaO + O2
2CaO2+ 2H2O → 2Ca2++ 4OH- + O2
The toxicity of the reaction mass is due to the hydrolysis product hydrogen peroxide (H2O2) and calcium hydroxide (Ca(OH)2). Under physiological conditions, calcium hydroxide ultimately dissociates into calcium cations (Ca2 +) and hydroxyl anions (OH-). Calcium, is an essential and abundantly available mineral nutrient. Hydroxyl anion is neutralised in body fluids.
Based on this information, DNELs for hydrogen peroxide and calcium hydroxide (or calcium) are presented:
Hydrogen peroxide:
No systemic effects caused by repeated oral or inhalation exposure to hydrogen peroxide were observed in the studies. This is considered to be due to the limited bioavailability of hydrogen peroxide. Consequently, it is not necessary to derive DNELs for systemic effects caused by long-term exposure. The DNEL for acute inhalation exposure is the occupational short-term exposure limit proposed by the SCOEL committee (SCOEL 2008) and the DNEL for long-term exposure is the occupational exposure limit set for hydrogen peroxide in most countries of the European Union (European Commission 2003). These limits are a STEL (15 min) of 3 mg/m3 and a 8h-TWA of 1.4 mg/m3.
Calcium hydroxide:
The Comission Directive (EU) 2017/194 established indicative occupational exposure limit values for calcium hydroxide. Therefore, no acute and long-term DNEL for workers exposed via inhalation are derived from animal studies. These limits, based on the recommendations of the Scientific Committee on Occupation Exposure Limits (SCOEL) are STEL (15 min) = 4 mg/m³ respirable dust for short-term exposure to prevent local sensory irritation due to the irritation potential of the substance, and 8 -h TWA = 1 mg/m³ respirable dust for long-term exposure to prevent local sensory irritation and decrease of lung function parameters as critical effects.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
Additional information - General Population
No uses are foreseen for the general population.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
