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EC number: 480-370-1 | CAS number: 21743-27-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2005-08-04 to 2005-09-06
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD Guideline under GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 92/69/EWG, C.1; OECD 203 (1992)
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 480-370-1
- EC Name:
- -
- Cas Number:
- 21743-27-1
- Molecular formula:
- Hill formula: C11H25NO4Si CAS formula: C11H25NO4Si
- IUPAC Name:
- 4-[(triethoxysilyl)methyl]morpholine
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 0 and 110 mg/L nominal (110 mg/L in duplicate)
- Time points: 0 and 96 h
- Sample storage conditions before analysis: freezer
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Identity and concentration of auxiliary solvent for dispersal: No vehicle used.
Test solutions were prepared according to the guidance document on aquatic toxicity testing of difficult substances:
A stock solution of the only test concentration of nominal 110 mg/l was prepared by dissolving 550 mg test item into 5000 ml test water by intense stirring for 24 h and additional short ultrasonic treatment for 5 min.
Since the test item undergoes rapid hydrolysis and as there was no specific analytical method available, analyses was performed by determination of the TOC (Total organic carbon) content as sum parameter in the test media.
At the start of the test the mean measured test item concentration was 111 mg/l. During the test period of 96 h a decrease of the test item concentration to 81.4 mg/l was determined. Therefore the biological results were related to the mean measured test item concentration 95.7 mg/l.
Test organisms
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- TEST ORGANISM
- Common name: Rainbow trout
- Strain: Oncorhynchus mykiss
- Source: Forellenzuchtbetrieb Wagenhausen, Bad Solgau, Germany
- Age at study initiation (mean and range, SD): juvenil
- Length at study initiation (length definition, mean, range and SD): 5.12 +/-0.21 cm
- Weight at study initiation (mean and range, SD): 1.34 +/- 0.1 g
- Method of breeding: not given
- Feeding during test: none
ACCLIMATION
- Acclimation period: 12 days
- Acclimation conditions (same as test or not): same as in test
- Type and amount of food: not given
- Feeding frequency: not given
- Health during acclimation (any mortality observed): 3 fish in the test fish batch
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Post exposure observation period:
- -
Test conditions
- Hardness:
- 250 mg CaCO3/L
- Test temperature:
- 15-16 °C
- pH:
- 7.6-7.9
- Dissolved oxygen:
- > 9.1 mg/L
- Salinity:
- 0.8 mmol/L
- Nominal and measured concentrations:
- nominal: 110 mg/L
measured (mean): 95.7 - Details on test conditions:
- TEST SYSTEM
- Test vessel: 20-Litre glass aquaria with 15 litre test medium
- No. of organisms per vessel: 7
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- Biomass loading rate: not given
TEST MEDIUM / WATER PARAMETERS
see above
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 h/d
- Light intensity: 450-550 lux
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
The test fish were observed after approximately 2, 24, 48, 72, 96 hours test duration for symptoms of intoxication and mortality.
TEST CONCENTRATIONS
- Limit test
- Range finding study
- Test concentrations: max. 100mg/L nominal
- Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 95.7 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- >= 95.7 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 95.7 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Basis for effect:
- other: toxic effects
- Details on results:
- - Behavioural abnormalities: no
- Observations on body length and weight: no
- Other biological observations:
- Mortality of control: no
- Other adverse effects control: no
- Abnormal responses: no
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: no
- Effect concentrations exceeding solubility of substance in test medium: no
After 96 h exposure, one fish at 95.7 mg test item displayed apathy. Since this effect appeared only in one out of seven fish at 95.7 mg test item/L and in addition to this, no dose dependent relationship was determined, the apathy was considered as not treatment relevant. - Results with reference substance (positive control):
- n.a.
- Reported statistics and error estimates:
- not applicable
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Since at a mean concentration of 95.7 mg/L no effect on the test organisms was observed, it can be assumed that the LC 50 is also higher than 100 mg/L. SLM 4490029 was not toxic to fish under the reported conditions.
- Executive summary:
To assess the acute toxicity of N-(Morpholinomethyl)triethoxysilane to fish a limit test according to OECD 203 (EU Guideline 92/92/EEC C.1) was performed. In the control and the only test concentration (95.7 mg/L mean measured conc.) no mortality and no treatment related toxic effects were observed. Since at a mean concentration of 95.7 mg/L no effect on the test organisms was observed, it can be assumed that the LC 50 is also higher than 100 mg/L. Based on this N-(Morpholinomethyl)triethoxysilane is not considerd to be toxic to fish.
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