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EC number: 218-691-4
CAS number: 2216-52-6
The dermal irritation potential of the test chemical was assessed in rabbits.
Hairless sites on the skin of 5 White rabbits were intradermally injected with 0.05ml of the test chemical. The dosing was repeated between 5 and 10 times. Gross examinations were made at 24 and 48 hours, at 1 and 2 weeks and in some cases 1 month following dosing. Microscopic examination of the skin was performed after the gross examination.
Moderate reactions characterized by polymorphonucelar leukocytes, and plasma cells(without necrosis) were noted in 3 rabbits. Severe reactions as well as necrosis were noted in the other 2 rabbits.
Hence,the test chemical can be considered to be a skin irritant.
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