Exo-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl propionate

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1973

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Remarks:

Study was performed predating current guidelines

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Reference

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1973

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Remarks:

Study was performed predating current guidelines

Reason / purpose for cross-reference:

reference to same study

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

no

Remarks:

Study was performed pre-GLP

Test type:

standard acute method

Limit test:

yes

Species:

rat

Strain:

not specified

Sex:

not specified

Route of administration:

oral: unspecified

Vehicle:

not specified

Doses:

5000 mg/kg bw

No. of animals per sex per dose:

10 animals in total

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations: daily
- Other examinations performed: clinical signs

Key result

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Mortality:

2 animals died during the 14 day observation period (day 3 and day 4).

Clinical signs:

other: Lethargy and urinary incontinence were observed

Interpretation of results:

other: Not acute harmful

Remarks:

in accordance with EU CLP (EC No.1272/2008 and its updates)

Conclusions:

The acute oral toxicity test showed an LD50 of > 5000 mg/kg bw

Executive summary:

A pre-GLP and pre-guideline study, equivalent to OECD TG 401, was performed to identify the acute oral toxicity of the test substance. In this study 10 rats (sex unspecified) were administered with 5000 mg/kg bw and observed for 14 days. 2/10 animals died on day 3 and 4. Clinical signs included lethargy and urinary incontinence. Under the conditions of the test, the acute oral LD50 for the test substance in rat was determined to exceed 5000 mg/kg bw. Based on these results, the test substance is not considered to be acute harmful following oral exposure.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1973

Report date:

1973

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

GLP compliance:

no

Remarks:

Study was performed pre-GLP

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

1

Reference substance name:

Exo-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl propionate

EC Number:

220-410-5

EC Name:

Exo-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl propionate

Cas Number:

2756-56-1

Molecular formula:

C13H22O2

IUPAC Name:

1,7,7-trimethylbicyclo[2.2.1]hept-2-yl propionate

Test material form:

liquid

Details on test material:

STORAGE CONDITIONS - Cool (<21C), dry area in sealed containers.

Test animals

Species:

rabbit

Strain:

not specified

Sex:

not specified

Administration / exposure

Type of coverage:

not specified

Vehicle:

not specified

Duration of exposure:

Not specified

Doses:

5000 mg/kg bw

No. of animals per sex per dose:

10 animals in total

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations: daily
- Other examinations performed: clinical signs

Results and discussion

Effect levels

Key result

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Mortality:

No mortality was observed in the 14-day observation period

Clinical signs:

other: No clinical signs were reported

Applicant's summary and conclusion

Interpretation of results:

other: Not acute harmful

Remarks:

in accordance with EU CLP (EC No. 1272/2008 and its updates)

Conclusions:

The acute dermal toxicity test showed an LD50 above 5000 mg/kg bw.

Executive summary:

A pre-GLP and pre-guideline study, equivalent to OECD TG 402, was performed to identify the acute dermal toxicity of the test substance. In this study 10 rabbits (sex unspecified) were exposed to 5000 mg/kg bw test substance on the skin. No mortality was observed in the 14 day observation period, and no clinical signs were noted. Under the conditions of the test, the acute dermal LD50 for the substance in rabbits exceeded 5000 mg/ kg bw. Based on these results, the test substance is not considered to be acutely harmful following dermal exposure.