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EC number: 480-060-6 | CAS number: 24065-33-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2005-11-03 to 2005-12-14
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- 24 April 2002
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 480-060-6
- EC Name:
- -
- Cas Number:
- 24065-33-6
- Molecular formula:
- Hill formula: C5H3ClO2S CAS formula: C5H3ClO2S
- IUPAC Name:
- 5-chlorothiophene-2-carboxylic acid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Remarks:
- HsdIf:NZW
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Harlan France, 03800 Gannat, France)
- Age at study initiation: Young adult animals
- Weight at study initiation: 2.3 kg — 2.5 kg
- Housing: The animals were housed individually in cage units Metall/Noryl by EBECO.
Excrement trays below the cages contained low dust wood granulate bedding (J. Rettenmaier & Söhne, 73494 Rosenberg, Germany).
- Diet (e.g. ad libitum): The animals received the standard diet “SsniffK-Z” 4mm (manufacturer: Ssniff Spezialdiieiten GmbH, 59494 Soest, Germany), approximately 100 g per animal per day
- Water (e.g. ad libitum): Tap water ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20±3
- Humidity (%): 50±25
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other:
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0,1 g - Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- 21 days
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Time after start of exposure: 24h
SCORING SYSTEM: According to DRAIZE
TOOL USED TO ASSESS SCORE: hand-slit lamp / biomicroscope / fluorescein: not reported
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0.7
- Max. score:
- 4
- Reversibility:
- fully reversible within: 3 days
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1.7
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 2.3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: #1, #2
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- iris score
- Basis:
- animal: #1 - #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: not applicable
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1.7
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 21 days
- Irritant / corrosive response data:
- There was corneal opacity in one animal with a score of 1.7 which was not reversible during the 21 experimental days, thus, the test item is considered corrosive to the eyes.
Any other information on results incl. tables
Animal |
| 24 h | 48 h | 72 h | Mean scores | Response | Reversible (days) |
1 | Corneal opacity | 0 | 2 | 3 | 1.7 | - | Not revers. |
Iritis | 0 | 0 | 0 | 0.0 | - | na | |
Redness conjunctivae | 2 | 2 | 2 | 2.0 | - | 14 | |
Chemosis conjunctivae | 2 | 2 | 1 | 1.7 | - | 7 | |
2 | Corneal opacity | 0 | 2 | 2 | 1.3 | - | 7 |
Iritis | 0 | 0 | 0 | 0.0 | - | na | |
Redness conjunctivae | 2 | 2 | 2 | 2.0 | - | 14 | |
Chemosis conjunctivae | 1 | 1 | 0 | 0.7 | - | 3 | |
3 | Corneal opacity | 0 | 2 | 2 | 1.3 | - | 14 |
Iritis | 0 | 0 | 0 | 0.0 | - | na | |
Redness conjunctivae | 2 | 3 | 2 | 2.3 | - | 14 | |
Chemosis conjunctivae | 1 | 1 | 1 | 1.0 | - | 7 | |
response: corneal opacity : mean scores < 2 = - , ≥ 2 < 3 = +; ≥ 3 = ++ iritis : mean scores < 1 = - , ≥ 1 < 2 = +; = 2 = ++ conjunctival redness : mean scores < 2.5 = - , ≥2.5 = + conjunctival oedema : mean scores < 2 = - ; ≥ 2 = + na : not applicable
|
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- According to classification criteria 5-Chlorthiophen-2-carbonsäure causes serious damage to eyes without reversibility within 21 days in one animal. There were no systemic intolerance reactions.
- Executive summary:
In a primary eye irritation study according to OECD test guideline 405 (2002), 0.1 g 5-Chlorthiophen-2-carbonsäure (100 % a.i.) were instilled into the conjunctival sac of one eye of 3 young adult New Zealand White rabbits for 24 hours. After 24 hours the eye was gently washed with physiological saline. Animals then were observed for 21 days. Irritation was scored by the method of Draize.
After application of 0.1 g of the test sample into the conjunctival sac, there were moderate reactions in the cornea that were not reversible in one animals within 21 days and initially stronger changes in the conjunctivae, which are completely reversible within 14 days. According to Regulation (EU) No. 1272/2008 (CLP) the test item is classified as Category 1 (irriversible effects to the to eye) based on the results obtained under the conditions described.
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