Registration Dossier
Registration Dossier
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EC number: 277-962-5 | CAS number: 74665-14-8
Endpoint summary
Administrative data
Description of key information
Corrosive
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The aromatic sulphonic acids, as represented by toluene-4-sulphonic acid (CAS No. 104-15-4) and hydroxybenzenesulphonic acid (CAS No. 1333-39-7) are corrosive to the skin and eye. Also sulphuric acid, the main component is corrosive for skin and eye. Therefore the substance is consequently classified.
A GLP guideline skin irritation study with toluene-4-sulphonic acid conducted in 1988 indicated corrosive properties after 4 hours of exposure; and the effects were not reversible after 7 days. 3-minute exposures followed by washing with water resulted in a much less severe effect that was reversible within 72 hours. During the test on sensitisation the primary skin irritation effect of 0.01 -20% solutions of toluene-4-sulphonic acid monohydrate in 0.9% NaCl solution was studied. The animals was exposed 24 hours to an occlusive application. An irritation effect was only found with 20%
toluene-4-sulphonic acid, but in a study by Loden et al (1985) with rabbits, without occlusion and after 4 hours, the same concentration in pure water solution caused burns.
A 1962, non-guideline eye irritation study with a 65% solution hydroxybenzenesulphonic acid indicated corrosion of the eye even after 5 seconds of exposure. There was no reversibility indicated within 14 days.
Justification for classification or non-classification
Based on existing tests the substance is classificated as "Corrosive" following Regulation 1272/2008. Based on existing studies a tested concentration < 20% didn't caused burns or irreversible effect. But the main component of the multiconsituent is sulphuric acid, for which the limit concentration is set to 15%, Therefore a concentration limit of 150% is set, under that the substance can be classified as "Irritant".
The substance is classified
H314: Causes severe skin burns and eye damage, Skin Corr. 1
H335: May cause respiratory irritation, STOT Single Exp. 3
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