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Physical & Chemical properties

Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
21 Feb. 2017 to 07 Apr. 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
OECD Guidelines for the Testing of Chemicals, Method No. 104, adopted 23. Mar. 2006: “Vapour Pressure“
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
Council Regulation (EC) No 761/2009 of 24 August 2009, Method A.4: “Vapour Pressure”
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
effusion method: Knudsen cell
Specific details on test material used for the study:
No further details specified in the study report.
Key result
Temp.:
20 °C
Vapour pressure:
0 Pa
Key result
Temp.:
25 °C
Vapour pressure:
0 Pa

Sample Weights

The mass of sample in the respective cell is presented in the following table:

Parameter

Cell empty

Cell + test item

Cell + test item + cap

Test item

Unit

g

g

g

g

Knudsen-cell 1

2.58925

3.65459

3.90980

1.06534

Knudsen-cell 2

2.60780

3.79185

4.04527

1.18405

Knudsen-cell 3

2.58065

3.65176

3.91139

1.07111

Knudsen-cell 4

2.59670

3.74607

4.00032

1.14937

 

Measurement Data

The data of the evaluated experiments is present in the following tables:

Measurement Data Experiment 1

Experiment

1

 

 

 

Nominal Temperature

30

°C

 

 

Date and time START

 

21.02.2017 12:10

22.02.2017 13:15

23.02.2017 12:25

Date and time END

 

22.02.2017 12:35

23.02.2017 11:30

24.02.2017 12:00*

Parameter

Weight m

Weight m

Weight m

Weight m

Unit

g

g

g

g

Knudsen-cell 1

3.90980

3.90944

3.90956

3.90953

Knudsen-cell 2

4.04527

4.04497

4.04497

4.04503

Knudsen-cell 3

3.91139

3.91113

3.91113

3.91114

Knudsen-cell 4

4.00032

3.99999

4.00005

4.00000

*Due to organizational reasons, the samples were stored in an exsiccator after weighing until the start of the next measurement series.

 

Measurement Data Experiment 2

Experiment

2

 

 

 

Nominal Temperature

45

°C

 

 

Date and time START

 

27.02.2017 11:50

28.02.2017 12:55

01.03.2017 12:35

Date and time END

 

28.02.2017 11:50

01.03.2017 11:30

02.03.2017 11:45

Parameter

Weight m

Weight m

Weight m

Weight m

Unit

g

g

g

g

Knudsen-cell 1

3.90953

3.90958

3.90978

3.90976

Knudsen-cell 2

4.04503

4.04508

4.04530

4.04525

Knudsen-cell 3

3.91114

3.91130

3.91145

3.91136

Knudsen-cell 4

4.00000

4.00022

4.00040

4.00037

 

Measurement Data Experiment 3

Experiment

3

 

 

 

Nominal Temperature

60

°C

 

 

Date and time START

 

02.03.2017 13:55

06.03.2017 12:10

07.03.2017 12:40

Date and time END

 

03.03.2017 11:50*

07.03.2017 11:50

08.03.2017 12:10

Parameter

Weight m

Weight m

Weight m

Weight m

Unit

g

g

g

g

Knudsen-cell 1

3.90976

3.90976

3.90976

3.90988

Knudsen-cell 2

4.04525

4.04548

4.04548

4.04555

Knudsen-cell 3

3.91136

3.91155

3.91155

3.91182

Knudsen-cell 4

4.00037

4.00037

4.00037

4.00038

*Due to organizational reasons, the samples were stored in an exsiccator after weighing until the start of the next measurement series.

 

Measurement Data Experiment 4

Experiment

4

 

 

 

Nominal Temperature

75

°C

 

 

Date and time START

 

08.03.2017 12:50

09.03.2017 11:55

13.03.2017 12:00

Date and time END

 

09.03.2017 11:00

10.03.2017 10:05*

14.03.2017 11:45

Parameter

Weight m

Weight m

Weight m

Weight m

Unit

g

g

g

g

Knudsen-cell 1

3.90988

3.90989

3.90988

3.90988

Knudsen-cell 2

4.04555

4.04554

4.04552

4.04552

Knudsen-cell 3

3.91182

3.91181

3.91182

3.91182

Knudsen-cell 4

4.00038

4.00037

4.00036

4.00036

*Due to organizational reasons, the samples were stored in an exsiccator after weighing until the start of the next measurement series.

 

Measurement Data Experiment 5

Experiment

5

 

 

 

Nominal Temperature

90

°C

 

 

Date and time START

 

14.03.2017 12:50

15.03.2017 12:35

16.03.2017 11:25

Date and time END

 

15.03.2017 11:45

16.03.2017 10:45

17.03.2017 11:50*

Parameter

Weight m

Weight m

Weight m

Weight m

Unit

g

g

g

g

Knudsen-cell 1

3.90988

3.91016

3.91016

3.91009

Knudsen-cell 2

4.04552

4.04588

4.04588

4.04588

Knudsen-cell 3

3.91182

3.91199

3.91199

3.91192

Knudsen-cell 4

4.00036

4.00084

4.00084

4.00063

*Due to organizational reasons, the samples were stored in an exsiccator after weighing until the start of the next measurement series.

 

Measurement Data Experiment 6

Experiment

6

 

 

 

Nominal Temperature

105

°C

 

 

Date and time START

 

20.03.2017 12:00

21.03.2017 12:40

22.03.2017 12:40

Date and time END

 

21.03.2017 11:50

22.03.2017 11:40

23.03.2017 11:45

Parameter

Weight m

Weight m

Weight m

Weight m

Unit

g

g

g

g

Knudsen-cell 1

3.91009

3.90893

3.90746

3.90746

Knudsen-cell 2

4.04588

4.04469

4.04324

4.04324

Knudsen-cell 3

3.91192

3.91103

3.90934

3.90934

Knudsen-cell 4

4.00063

3.99936

3.99772

3.99772

 

Measurement Data Experiment 7

Experiment

7

 

 

 

Nominal Temperature

120

°C

 

 

Date and time START

 

23.03.2017 12:30

27.03.2017 12:20

28.03.2017 12:40

Date and time END

 

24.03.2017 10:50*

28.03.2017 11:45

29.03.2017 11:50

Parameter

Weight m

Weight m

Weight m

Weight m

Unit

g

g

g

g

Knudsen-cell 1

3.90746

3.90570

3.90401

3.90300

Knudsen-cell 2

4.04324

4.04108

4.03995

4.03903

Knudsen-cell 3

3.90934

3.90581

3.90361

3.90249

Knudsen-cell 4

3.99772

3.99553

3.99375

3.99278

*Due to organizational reasons, the samples were stored in an exsiccator after weighing until the start of the next measurement series.

 

Measurement Data Experiment 8

Experiment

8

 

 

 

Nominal Temperature

135

°C

 

 

Date and time START

 

29.03.2017 12:35

30.03.2017 12:45

03.04.2017 12:25

Date and time END

 

30.03.2017 11:55

31.03.2017 11:50*

04.04.2017 12:00

Parameter

Weight m

Weight m

Weight m

Weight m

Unit

g

g

g

g

Knudsen-cell 1

3.90300

3.89903

3.89619

3.89263

Knudsen-cell 2

4.03903

4.03496

4.03210

4.02877

Knudsen-cell 3

3.90249

3.89822

3.89547

3.89128

Knudsen-cell 4

3.99278

3.98821

3.98297

3.97796

*Due to organizational reasons, the samples were stored in an exsiccator after weighing until the start of the next measurement series.

 

Measurement Data Experiment 9

Experiment

9

 

 

 

Nominal Temperature

150

°C

 

 

Date and time START

 

04.04.2017 20:40

05.04.2017 12:40

06.04.2017 10:15

Date and time END

 

05.04.2017 12:00

06.04.2017 09:30

07.04.2017 07:00

Parameter

Weight m

Weight m

Weight m

Weight m

Unit

g

g

g

g

Knudsen-cell 1

3.89263

3.87780

3.86281

3.85070

Knudsen-cell 2

4.02877

4.01500

4.00106

3.98979

Knudsen-cell 3

3.89128

3.87835

3.86517

3.85452

Knudsen-cell 4

3.97796

3.95959

3.94131

3.92696

 

Observations

120 °C: At the first measurement of experiment 7, all cells were slightly contaminated. Therefore, the cells were meticulously cleaned and weighed. This weight was used as initial weight for the subsequent measurements. To avoid bias, this measurement was not used for calculations.

120 °C: At the second measurement of experiment 7, cell 3 was slightly contaminated. Therefore, the cell was meticulously cleaned and weighed. This weight was used as initial weight for the subsequent measurements. To avoid bias, this measurement was not used for calculations.

 

Calculation Results

All calculation results are given below.

In all tables, E-0X represents multiplication with 10-x. The first six experiments showed no relevant or reproducible weight loss. Therefore, they were not used for the calculation of the result.

 

Calculation Results Experiment 7

Experiment

7

 

 

 

 

 

 

 

 

Real Temperature in K

393.2

 

 

 

 

 

 

 

 

Real Temperature in °C

120.0

 

 

 

 

 

 

 

 

Date of Measurement

24.03.2017 10:50

28.03.2017 11:45

29.03.2017 11:50

Elapsed Time in s

80400

84300

83400

Parameter

Weight loss

To be used

Vapour pressure

Weight loss

To be used

Vapour pressure

Weight loss

To be used

Vapour pressure

Unit

g

yes/no

Pa

g

yes/no

Pa

g

yes/no

Pa

Knudsen-cell 1

0.00176

yes

5.28E-03

0.00169

yes

4.84E-03

0.00101

yes

2.92E-03

Knudsen-cell 2

0.00216

yes

6.48E-03

0.00113

yes

3.23E-03

0.00092

yes

2.66E-03

Knudsen-cell 3

0.00353

yes

1.06E-02

0.00220

no

 

0.00112

yes

3.24E-03

Knudsen-cell 4

0.00219

yes

6.57E-03

0.00178

yes

5.10E-03

0.00097

yes

2.81E-03

Mean

 

no

 

 

yes

4.39E-03

 

yes

2.91E-03

Standard deviation:

 

 

 

 

 

1.01E-03

 

 

2.46E-04

Mean of measured values:

 

3.649E-03

 

 

 

 

 

 

Standard deviation:

 

1.048e-03

RSD:

 

28.7%

 

 

 

 

Calculation Results Experiment 8

Experiment

8

 

 

 

 

 

 

 

 

Real Temperature in K

408.2

 

 

 

 

 

 

 

 

Real Temperature in °C

135.0

 

 

 

 

 

 

 

 

Date of Measurement

30.03.2017 11:55

31.03.2017 11:50

04.04.2017 12:00

Elapsed Time in s

84000

83100

84900

Parameter

Weight loss

To be used

Vapour pressure

Weight loss

To be used

Vapour pressure

Weight loss

To be used

Vapour pressure

Unit

g

yes/no

Pa

g

yes/no

Pa

g

yes/no

Pa

Knudsen-cell 1

0.00397

yes

1.16E-02

0.00284

yes

8.40E-03

0.00356

yes

1.03E-02

Knudsen-cell 2

0.00407

yes

1.19E-02

0.00286

yes

8.46E-03

0.00333

yes

9.64E-03

Knudsen-cell 3

0.00427

yes

1.25E-02

0.00275

yes

8.14E-03

0.00419

yes

1.21E-02

Knudsen-cell 4

0.00457

yes

1.34E-02

0.00524

yes

1.55E-02

0.00501

yes

1.45E-02

Mean

 

yes

1.24E-02

 

yes

1.01E-02

 

yes

1.16E-02

Standard deviation:

 

 

7.74E-04

 

 

3.59E-03

 

 

2.18E-03

Mean of measured values:

 

1.138E-02

 

 

 

 

 

 

Standard deviation:

 

1.138E-03

RSD:

 

10.0%

 

 

 

 

Calculation Results Experiment 9

Experiment

9

 

 

 

 

 

 

 

 

Real Temperature in K

423.2

 

 

 

 

 

 

 

 

Real Temperature in °C

150.0

 

 

 

 

 

 

 

 

Date of Measurement

05.04.2017 12:00

06.04.2017 09:30

07.04.2017 07:00

Elapsed Time in s

84000

75000

74700

Parameter

Weight loss

To be used

Vapour pressure

Weight loss

To be used

Vapour pressure

Weight loss

To be used

Vapour pressure

Unit

g

yes/no

Pa

g

yes/no

Pa

g

yes/no

Pa

Knudsen-cell 1

0.01483

yes

4.42E-02

0.01499

yes

5.00E-02

0.01211

yes

4.06E-02

Knudsen-cell 2

0.01377

yes

4.10E-02

0.01394

yes

4.65E-02

0.01127

yes

3.78E-02

Knudsen-cell 3

0.01293

yes

3.85E-02

0.01318

yes

4.40E-02

0.01065

yes

3.57E-02

Knudsen-cell 4

0.01837

yes

5.48E-02

0.01828

yes

6.10E-02

0.01435

yes

4.81E-02

Mean

 

yes

4.46E-02

 

yes

5.04E-02

 

yes

4.05E-02

Standard deviation:

 

 

7.13E-03

 

 

7.50E-03

 

 

5.24E-03

Mean of measured values:

 

4.519E-02

 

 

 

 

 

 

Standard deviation:

 

4.954E-03

RSD:

 

11.0%

 

 

 

 

Conclusions:
For the test item Hatcol 3178, the following vapour pressures at 20°C and at 25°C were calculated from the regression equation:
Vapour pressure at 20°C: 1.93 * 10-08 Pa
Vapour pressure at 25°C: 4.28 * 10-08 Pa
The linear regression of log P vs. 1/T gave a correlation coefficient r of - 0.9971, showing good repeatability and precision. Therefore, the determination is considered as valid.
Executive summary:

This study was performed in order to determine the vapour pressure of Hatcol 3178. The vapour pressure is one of the physical-chemical properties of a substance and needed for risk assessments. The method is based on the estimation of the mass of test item flowing out per unit of time of a Knudsen cell in the form of vapour, through a micro-orifice under ultra-vacuum conditions. The mass of effused vapour is obtained by determining the loss of mass of the cell. The vapour pressure is calculated by applying the Hertz-Knudsen relation. The recommended range is 10–10to 1 Pa.

 

The vapour pressure of Hatcol 3178 was determined following EU A.4 using the effusion method (weight loss).

 

Vapour pressure was examined at nine different temperatures. Three temperatures could be evaluated as they showed reproducible weight loss. For these temperatures, 1/T was plotted against log (P).

 

Vapour Pressures (Effusion Method)

Experiment

T

Mean P

Stand. Dev. P

RSD P

No.

K

Pa

Pa

%

7

393.2

3.65E-03

1.05E-03

28.7%

8

408.2

1.14E-02

1.14E-03

10.0%

9

423.2

4.52E-02

4.95E-03

11.0%

In this table, E-0X represents multiplication with 10-X.

Stand. Dev. = Standard Deviation; RSD = Relative Standard Deviation

 

The graph 1/T vs. log (P) shows a straight line with a correlation coefficient of - 0.9971.

 

For the test item Hatcol 3178, the following vapour pressures at 20 °C and at 25 °C were calculated from the regression equation:

Vapour pressure at 20 °C: 1.93 * 10-08Pa

Vapour pressure at 25 °C: 4.28 * 10-08Pa

Description of key information

For the test item Hatcol 3178, the following vapour pressures at 20 °C and at 25 °C were calculated from the regression equation:

Vapour pressure at 20 °C: 1.93 * 10-08Pa

Vapour pressure at 25 °C: 4.28 * 10-08Pa

Key value for chemical safety assessment

Vapour pressure:
0 Pa
at the temperature of:
25 °C

Additional information

The method is based on the estimation of the mass of test item flowing out per unit of time of a Knudsen cell in the form of vapour, through a micro-orifice under ultra-vacuum conditions. The mass of effused vapour is obtained by determining the loss of mass of the cell. The vapour pressure is calculated by applying the Hertz-Knudsen relation. The recommended range is 10–10to 1 Pa.

 

The vapour pressure of Hatcol 3178 was determined following EU A.4 using the effusion method (weight loss).

 

Vapour pressure was examined at nine different temperatures. Three temperatures could be evaluated as they showed reproducible weight loss. For these temperatures, 1/T was plotted against log (P).

Vapour Pressures (Effusion Method)

Experiment

T

Mean P

Stand. Dev. P

RSD P

No.

K

Pa

Pa

%

7

393.2

3.65E-03

1.05E-03

28.7%

8

408.2

1.14E-02

1.14E-03

10.0%

9

423.2

4.52E-02

4.95E-03

11.0%

In this table, E-0X represents multiplication with 10-X.

Stand. Dev. = Standard Deviation; RSD = Relative Standard Deviation

 

The graph 1/T vs. log (P) shows a straight line with a correlation coefficient of - 0.9971.

 

For the test item Hatcol 3178, the following vapour pressures at 20 °C and at 25 °C were calculated from the regression equation:

Vapour pressure at 20 °C: 1.93 * 10-08Pa

Vapour pressure at 25 °C: 4.28 * 10-08Pa