Registration Dossier
Registration Dossier
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EC number: 233-143-4 | CAS number: 10043-84-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- data is from safety assessment reports
Data source
Reference
- Reference Type:
- secondary source
- Title:
- INVENTORY MULTI-TIERED ASSESSMENT AND PRIORITISATION (IMAP) - NICNAS
- Author:
- National Industrial Chemicals Notification and Assessment Scheme (NICNAS)
- Year:
- 2 018
- Bibliographic source:
- INVENTORY MULTI-TIERED ASSESSMENT AND PRIORITISATION (IMAP) - NICNAS, 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- To assess the dermal irritation potential of the test chemical
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Manganese dichloride
- EC Number:
- 231-869-6
- EC Name:
- Manganese dichloride
- Cas Number:
- 7773-01-5
- Molecular formula:
- Cl2Mn
- IUPAC Name:
- Manganese chloride
- Test material form:
- solid
- Details on test material:
- Name of the test chemical:
Manganese dichloride
Molecular Formula:Cl2Mn
Molecular Weight: 125.844 g/mol
Substance Type: Inorganic
Physical State: Solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- sex: male
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- not specified
- Amount / concentration applied:
- 0.5 g of test chemical (mixed with 0.5 mL of distilled water to create a paste)
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 24 hours till 7 days
- Number of animals:
- 3 male
- Details on study design:
- SCORING SYSTEM: The test sites were scored for erythema and edema after 24 hours
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 2
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 1
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- One rabbit showed erythema (score = 2) and oedema (score = 1) at 24 hours postexposure, both of which were reversed by seven days post-exposure
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- One rabbit showed erythema (score = 2) and oedema (score = 1) at 24 hours postexposure, both of which were reversed by seven days post-exposure.
Since the effects were reversible in 7 days, hence the test chemical was considered to be not irritating to skin. - Executive summary:
The dermal irritation potential of the test chemical was assessed in rabbits according to OECD 404 Guidelines.0.5 g of the test chemical (mixed with 0.5 ml of distilled water to create a paste) was applied to the shaven skin of 3 male New Zealand White rabbits under semi-occlusive conditions for 4 hours. The test sites were observed for erythema and edema 24 hours post exposure till 7 days.
One rabbit showed erythema (score = 2) and oedema (score = 1) at 24 hours postexposure, both of which were reversed by seven days post-exposure.
Since the effects were reversible in 7 days, hence the test chemical was considered to be not irritating to skin
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