Dysprosium trinitrate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1963

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

publication

Title:

The Acute Mammalian Toxicity of Rare Earth Nitrates and Oxides

Author:

Bruce DW, Hietbrink BE, DuBois KP

Year:

1963

Bibliographic source:

Toxicology and Applied Pharmacology 5, 750-759

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Version / remarks:

before 2002

Deviations:

not specified

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Dysprosium trinitrate

EC Number:

233-410-5

EC Name:

Dysprosium trinitrate

Cas Number:

10143-38-1

Molecular formula:

Dy.3HNO3

IUPAC Name:

dysprosium trinitrate

Test material form:

solid - liquid: aqueous solution

Details on test material:

- Dy(NO3)3.6H2O (hydrated form) was used as test item.
- Source: RE nitrates were obtained from the Lindsay Chemical Company, West Chicago, Illinois & K and K Laboratories, Jamaica, New York
- Purity: > 98%
- A 50% aqueous solution was used for dosing.

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: no data
- Females (if applicable) nulliparous and non-pregnant: no data
- Age at study initiation: adult
- Weight at study initiation: 190-250 g
- Fasting period before study: no data
- Housing: air-conditioned quarters
- Diet (e.g. ad libitum): ad libitum, Rockland Rat Diet
- Water (e.g. ad libitum): ad libitum
- Acclimation period: no data

ENVIRONMENTAL CONDITIONS
- Temperature (°C): air-conditioned
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

- Concentration in vehicle: 50% suspension
- Amount of vehicle (if gavage): no data

Doses:

5000 mg/kg bw

No. of animals per sex per dose:

20 females

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 30 days
- Other examinations performed: clinical signs

Statistics:

LD50 and 95% confidence limits were calculated by the method of Litchfield and Wilcoxon (1949).

Results and discussion

Effect levels

Key result

Sex:

female

Dose descriptor:

LD50

Effect level:

3 100 mg/kg bw

Based on:

test mat.

95% CL:

2 870 - 3 348

Mortality:

No data

Clinical signs:

other: Within 1 to 2 h after oral administration of RE nitrates most of the rats were depressed, and animals that received lethal doses showed little activity during the survival period. The animals were observed for 30 days although no deaths occurred later tha

Gross pathology:

Throughout the observation period no gross pathological changes were noted.

Other findings:

No data

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The LD50 of dysprosium trinitrate for female rats following oral administration was found to be 3100 mg/kg body weight, with 95% confidence limits of 2870-3348 mg/kg body weight.