Registration Dossier
Registration Dossier
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EC number: 225-083-2 | CAS number: 4651-67-6
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no study available
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Skin corrosion/irritation
Experimental data on the potential of skin corrosion or irritation of 3-α-hydroxy-7-oxo-5-β-cholan-24-oic acid are not available.
QSAR Toolbox, has identified one structural alert for skin irritation (Ketones). Substances with "Ketones" structural alert can cause irritation of the skin as proposed by Hulzebos et al. In particular, ketones are considered “possible irritants”.
However, considering domains applicability (skin irritation potential, can be related to a combination of MW and log Pow, e.g., chemicals with MW< 200 and log Pow of >2 had enhanced skin irritation potential) the substance is out of the domain because MW is > 200.
In order to estimates skin irritation potential from physicochemical property ranges and structural rules, the software Toxtree (v.2.6.13) has been used; prediction is “not irritating or corrosive to skin”.
Overall, hazard class "Skin corrosion/irritation" are judged as inconclusive for the classification.
Serious eye damage/eye irritation
Experimental data on the potential of eye corrosion or irritation of 3-α-hydroxy-7-oxo-5-β-cholan-24-oic acid are not available.
QSAR Toolbox has not identified any structural alert for eye irritation.
In order to estimates eye irritation potential from physicochemical property ranges and structural rules, the software Toxtree (v.2.6.13) has been used; prediction is “not skin corrosion R34 or R35”.
Overall, hazard class "Serious eye damage/eye irritation" are judged as inconclusive for the classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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